We have exploited a typically undesired elementary step in cross-coupling reactions, β-hydride elimination, to accomplish palladium-catalyzed dehydrohalogenations of alkyl bromides to form terminal olefins. We have applied this method, which proceeds in excellent yield at room temperature in the presence of a variety of functional groups, to a formal total synthesis of (R)-mevalonolactone. Our ...

The molecular calcium hydride, [(BDI)CaH]2 (BDI = HC{(Me)CN-2,6-i-Pr2C6H3}2), effects the slow hydrodehalogenation of C6H5X (X I, Br) to provide benzene and respective dimeric halides, [(BDI)CaX]2. Although a similar reaction with fluorobenzene was non-discriminating, analogous hydrogenation chlorobenzene observed, albeit this process yields hydride-chloride as alkaline earth-containing product...

6Li and 15N NMR spectroscopic studies show that hexane solutions of LDA containing <1.0 equiv of N,N,N′,N′′,N′′-pentamethyldiethylenetriamine (PMDTA) per lithium contain a mixture of unsolvated LDA oligomers, monosolvated open dimer, and monosolvated monomer. At >1.0 equiv of PMDTA per lithium, monomer is the dominant species. Addition of PMDTA to LDA in toluene affords open dimer at low [PMDTA...

Dichloromethane (DCM) is a volatile halogenated hydrocarbon with teratogenic, mutagenic and carcinogenic effects. Biodegradation generally regarded as an effective economical approach of pollutant disposal. In this study, novel strain was isolated its cytochrome P450 heterologously expressed for DCM degradation. The isolate, Microbacterium keratanolyticum ZY, characterized Gram-positive, rod-sh...

Chloromuconate cycloisomerases of bacteria utilizing chloroaromatic compounds are known to convert 3-chloro-cis,cis-muconate to cis-dienelactone (cis-4-carboxymethylenebut-2-en-4-olide), while usual muconate cycloisomerases transform the same substrate to the bacteriotoxic protoanemonin. Formation of protoanemonin requires that the cycloisomerization of 3-chloro-cis,cis-muconate to 4-chloromuco...

After an exhaustive study of the system ammonia-dimethylchloramine in liquid ammonia, it was interesting to compare the reactivity of this system in liquid ammonia with the same systeme in an aqueous medium. Dimethylchloramine prepared in a pure state, undergoes dehydrohalogenation in an alkaline medium: the principal products formed are Nmethylmethanimine, 1,3,5-trimethylhexahydrotriazine, for...