It is now well recognized that idiopathic chondrocalcinosis articularis, as well as being associated with acute episodes of pyrophosphate arthropathy, may lead to premature degenerative changes in the joints involved. Some workers have also made occasional reference to the presence of juxta-articular osteolytic lesions (McCarty, Kohn, and Faires, 1962; Currey, 1970.) More recently there have be...

A 46-year-old man of mixed race had been followed up for the past 7 years at our Rheumatology clinic. He was labelled as ‘burnt out’ rheumatoid arthritis with secondary osteoarthritis. Methotrexate had been stopped 5 years ago. His main complaint was chronic lower backache that had been worsening over the past few years. He did not have any symptoms suggestive of an inflammatory arthropathy. Hi...

Background: Alkaptonuria (AKU) or ochronosis is a rare progressive degenerative arthropathy that results from deficiency of enzyme homogentisate 1,2 dioxygenase (HGD). The features include arthritis of the spine and in larger peripheral joints, with chondrocalcinosis. In this paper, we present a case of alkaptonuria in a 54 year old woman in Tehran, Iran. Case Presentation: A 54 year old woman ...

Arthroplasty is used to relieve pain associated with degenerative or inflammatory joint disease, some post-traumatic joint problems, and avascular necrosis. Avascular necrosis, inflammatory and post-traumatic problems are seen on a regular basis in areas of high HIV seroprevalence. Degenerative arthritis is rare in younger HIV patients, however. Historically the only group of HIV patients in wh...

This study is aimed at evaluating the short-term effects of a single corticosteroid injection of the acromioclavicular joint on the range of motion of the shoulder joint using a three dimensional electromagnetic tracking system (FASTRAK) in patients with isolated unilateral acromioclavicular joint (ACJ) arthropathy. Eighteen patients (16 male, 2 female; mean age: 47.53 years), with isolated uni...

The temporomandibular joint (TMJ) connects the mandible to the skull. TMJ disorders induce degenerative tissue changes in TMJ disc that are largely the result of maladaption to abnormal joint loading. Histopathological studies have documented an association between TMJ arthropathy and loss of tissue cellularity, via apoptosis-related processes, that result in diminished extracellular matrix gen...

In patients with haemophilia, regular replacement therapy with clotting factor concentrates (prophylaxis) is effective in preventing recurrent bleeding episodes into joints and muscles. However, despite this success, intra-articular and intramuscular bleeding is still a major clinical manifestation of the disease. Bleeding most commonly occurs in the knees, elbows, and ankles, and is often evid...