Receptive fields of neurons in cortical area V4 are large enough to fit multiple stimuli, making V4 the ideal place to study the effects of selective attention at the single-neuron level. Experiments have revealed evidence for stimulus competition and have characterized the effect thereon of spatial and feature-based attention. We developed a biophysical model with spiking neurons and conductan...

Fatal familial insomnia (FFI) is an autosomal dominant prion disease clinically characterized by rapidly progressive insomnia, prominent autonomic alterations and behavioral disturbance. The D178N mutation of the prion protein gene (PRNP) on chromosome 20 in conjunction with methionine at codon 129 is a molecular feature. Although the neuropatholo...

BACKGROUND In absence of a positive family history, the diagnosis of fatal familial insomnia (FFI) might be difficult because of atypical clinical features and low sensitivity of diagnostic tests. FFI patients usually do not fulfil the established classification criteria for Creutzfeldt-Jakob disease (CJD); therefore, a prion disease is not always suspected. OBJECTIVE To propose an update of ...

The descriptional complexity of semi-conditional grammars is studied. A proof that every recursively enumerable language is generlji";'I":ff f iru*::?H:"ffi Xl,?li".ffi f iJ,,-,T?,ll,J"'"'n'"

Do developing countries derive benefits from foreign financial investment (FFI) in the same way as they do from FDI? Through analyses in a stylized framework of foreign investment, this paper concludes that due to the lack of well functioning financial markets and the lack of technology, FFI flows may not be allocated and utilized as efficiently in developing countries as FDI. The frequently cl...

The prediction of diffuse herbicide losses to surface waters using process-based models is data and time demanding. There is a need for simpler and more efficient catchment screening tools. We developed and tested a new proxy for screening catchments for their vulnerability to diffuse herbicide losses relying on widely available river flow data only. The proxy combines the fast flow index (FFI)...

BACKGROUND Sporadic fatal insomnia (sFI) and fatal familial insomnia (FFI) are rare human prion diseases. CASE PRESENTATION We report a case of a 33-year-old female who died of a prion disease for whom the diagnosis of sFI or FFI was not considered clinically. Following death of this patient, an interview with a close family member indicated the patient's illness included a major change in he...

A crucial tenet of the prion hypothesis is that misfolding of the prion protein (PrP) induced by mutations associated with familial prion disease is, in an otherwise normal mammalian brain, sufficient to generate the infectious agent. Yet this has never been demonstrated. We engineered knockin mice to express a PrP mutation associated with a distinct human prion disease, fatal familial insomnia...

The goal was to examine the nature of social anhedonia using two validated measures and study their relationship to scores on the NEO-Five Factor Inventory (NEO-FFI). Nearly 1,900 college-aged participants completed the Chapman Revised Social Anhedonia Scale (RSAS), Anticipatory and Consummatory Interpersonal Pleasure Scale (ACIPS), and the NEO-FFI. Although both the RSAS and ACIPS were associa...