To an evolutionary geneticist, the most important property of a new mutation is its effect on fitness. Stress is a reduction in fitness that can also alter the selection on new mutations. Although the effects of environmental and genetic stresses are typically studied separately, it is useful to consider them from the same perspective. Here we evaluate the common perception that stress increase...

It has been claimed recently that it may be possible to predict the rate of de novo mutation of each site in the human genome with a high degree of accuracy [Michaelson et al. (2012), Cell 151: 1431-1442]. We show that this claim is unwarranted. By considering the correlation between the rate of de novo mutation and the predictions from the model of Michaelson et al., we show there could be sub...

Liquid chromatography combined with tandem mass spectrometry (LC-MS/MS) is an important tool in proteomics for identifying the peptides in a sample. Liquid chromatography temporally separates the peptides and tandem mass spectrometry analyzes the peptides, that elute one after another, by measuring their mass-to-charge ratios and the mass-to-charge ratios of their prefix and suffix fragments. D...

the effects of camp-analogue dibutyryl-camp and anticalmodulin w-7 were studied on de novo synthesis and secretion of lipids in cultures of hepatoma mcardle rh7777 cells and normal rat hepatocytes. dibutyryl-camp and w -7 separately caused a significant decrease in the secretion of de novo synthesized triacyl [3h]glycerol in both cultures of mcardle cells and rat hepatocytes. the inhibitory eff...

It has been almost half a century since Leo Kanner first described the clinical phenotype associated with Autism1. Since Kanner's descriptions, much effort has been devoted to understanding and identifying the factors which may contribute to Autism. It was not until the early 80’s that compelling evidence started to accumulate suggesting that Autism is a disorder of abnormal brain development. ...

Multi-objective De Novo linear programming (MODNLP) is problem for designing optimal system by reshaping the feasible set (Fiala [3] ). This paper deals with MODNLP having possibilistic objective functions coefficients. The problem is considered by inserting possibilistic data in the objective functions coefficients. The solution of the problem is defined and established under the using of effi...

Objective To verify the hypothesis that the incidence of chromosomal abnormalities increases in babies conceived by different assisted reproduction procedures. The availability of the umbilical cord blood encouraged us to study this hypothesis via this method. MaterialsAndMethods This is a descriptive study, umbilical cord blood samples of assisted reproductive technology (ART) children were an...