Poor mathematical abilities adversely affect academic and career opportunities. The neuroanatomical basis of developmental dyscalculia (DD), a specific learning deficit with prevalence rates exceeding 5%, is poorly understood. We used structural MRI and diffusion tensor imaging (DTI) to examine macro- and micro-structural impairments in 7- to 9-year-old children with DD, compared to a group of ...

Studying the biological mechanisms underlying mental retardation and developmental disabilities (MR/DD) is a very complex task. This is due to the wide heterogeneity of etiologies and pathways that lead to MR/DD. Breakthroughs in genetics and molecular biology and the development of sophisticated brain imaging techniques during the last decades have facilitated the emergence of a field called B...

The Death Domain (DD) superfamily, which is one of the largest classes of protein interaction modules, plays a pivotal role in apoptosis, inflammation, necrosis and immune cell signaling pathways. Because aberrant or inappropriate DD superfamily-mediated signaling events are associated with various human diseases, such as cancers, neurodegenerative diseases and immunological disorders, the stud...

background: safe exclusion and risk stratification are currently recommended for the initial management of patients with acute pulmonary embolism (ape). the aim of this study was to assess the safe exclusion and risk stratification value of d-dimer (dd) for ape when tested at the beginning of admission. materials and methods: all consecutive chinese ape patients and controls were recruited from...

BACKGROUND The life-cycle of cellular slime molds comprises chronobiologically regulated processes. During the growth phase, the amoeboid cells proliferate at a definite rate. Upon starvation, they synthesize cAMP as both first and second messengers in signalling pathways and form aggregates, migrating slugs, and fruiting bodies, consisting of spores and stalk cells, within 24 h. In Dictyosteli...

Background: Inactivation of p53 and reactivation of telomerase expression are two of the most common events in human cancer. Results: Here we report the mechanisms used by p53, p63, and p73 to suppress telomerase expression. Conclusion: p53, p63, and p73 suppress telomerase expression through distinct pathways that involve E2F, E-box, c-Myc, and NF-YB. Significance: This study provides new insi...

results in the first three years, the team managed the care of 812 admissions. mean age wasn 44.3 years (sd = 24.8) and mean length of hospital stay was 6.1 days (sd = 10.9). ofn these individuals, 674 attended for 6 month follow-up with 52.2% having a good outcomen on extended glasgow outcome score. patients and their relatives' feedbacks weren excellent with an average score of 4.7/5 on overa...

Dupuytren's disease (DD) is an ill-defined fibroproliferative disorder affecting the palm of the hand, resulting in progressive and irreversible digital contracture. In view of the abnormal gene dysregulation found in DD, and its potential effect on metabolites at a functional level, we chose to examine the metabolic profile involved in DD. Using Fourier transform infrared (FT-IR) spectroscopy ...

conclusions the established method has an acceptable performance in quantifying yb-1. in addition, serum yb-1 may aid in the diagnosis of hcc. results the developed method was linear to 150 μg/l of yb-1 with a minimum detection limit of 0.01 μg/l. the average recoveries were between 93.9% and 109.0%. the mean intra- and inter-assay coefficients of variation (cvs) were 4.0-4.8% and 8.2-10.2%, re...