نتایج جستجو برای: daudi

تعداد نتایج: 432  

Journal: :journal of basic research in medical sciences 0
morteza yaftian blood transfusion research center, high institute for research and education in transfusion medicine, tehran, iran fatemeh yari blood transfusion research center, high institute for research and education in transfusion medicine, tehran, iran mehran ghasemzadeh blood transfusion research center, high institute for research and education in transfusion medicine, tehran, iran

introduction: it has been reported that platelets can eradicate tumor cells in vitro, although the mechanism of this effect has not been determined. the effect of platelets on the induction of apoptosis in tumor cells is largely unknown. materials and methods: to investigate this effect, two human hematologic cell lines, k562 and daudi, were independently faced with unstimulated and thrombin-ac...

Journal: :Journal of immunology 2007
Chuan He Yang Lai Wei Susan R Pfeffer Ziyun Du Aruna Murti William J Valentine Yi Zheng Lawrence M Pfeffer

IFNs selectively regulate gene expression through several signaling pathways. The present study explored the involvement of STAT3 in the IFN-induced expression of the gene encoding the CXCL11 chemokine. The CXCL11 gene was induced in IFN-sensitive Daudi cells, but not in an IFN-resistant DRST3 subline with a defective STAT3 signaling pathway. Although the IFN-stimulated gene ISG15 was induced t...

2014
Maximillian Rosario Bai Liu Lin Kong Stephanie E Schneider Emily K Jeng Peter R Rhode Hing C Wong Todd A Fehniger

NK cells are innate lymphoid cells that mediate potent anti-tumor responses against B cell malignancies in conjunction with anti-CD20 mAbs. ALT-803 is a superagonist IL-15 and dimeric IL-15Ra-IgG-Fc fusion protein that effectively trans-presents IL-15 and exhibits prolonged in vivo pharmacokinetics compared to rhIL-15. We hypothesized that ALT-803 will augment anti-CD20 mAb (rituximab)-directed...

Journal: :The Journal of Experimental Medicine 1994
M D Maloney C A Lingwood

The glycosphingolipid globotriaosyl ceramide (CD77) and other globo-series glycolipids containing terminal galactose (Gal)alpha 1-4Gal residues function as receptors for the verotoxin (Shiga-like toxin) family of Escherichia coli-elaborated toxins. CD77 is also a marker for germinal center B lymphocytes and Burkitt's lymphoma cells. The pan B cell marker CD19 is a 95-kD membrane protein that ap...

Journal: :Cancer research 1989
W M Vuist F v Buitenen M A de Rie A Hekman P Rümke C J Melief

To study the immunotherapeutic potential of monoclonal antibodies (mAbs) directed against the human pan-B-cell antigen CD19, a xenotransplantation model was developed in which the human Burkitt's cell line Daudi is s.c. transplanted into nude mice. IgG1, IgG2b, and IgG2a isotype variants of the anti-CD19 mAb (CLB-CD19) were tested for their capacity to inhibit the growth of 10 x 10(6) Daudi cel...

Journal: :Pharmaceuticals 2021

Histone deacetylase (HDAC) inhibitors are a class of drugs used in the cancer treatment. Here, we developed library 19 analogues Vorinostat, an HDAC inhibitor lymphomas In replaced hydrophobic phenyl group with various tricyclic ‘caps’ possessing central, eight-membered, heterocyclic ring, and investigated activity cytotoxic effect on normal cell lines. We found that 3 out compounds, based dibe...

Journal: :Journal of immunology 2004
Dai Iwakiri Kenzo Takada

B cell Ag receptor (BCR) cross-linking with anti-Ig Abs efficiently induces activation of latently infected EBV in some B cell lines, but not in others. The present study was aimed at defining the molecular mechanisms that determine the response to BCR-mediated EBV activation. Comparison of Burkitt's lymphoma-derived Akata, Mutu-I, and Daudi cells, which are representative responders and nonres...

Journal: :The Journal of Cell Biology 1993
S S Evans R P Collea M M Appenheimer S O Gollnick

The L-selectin homing receptor expressed by lymphocytes mediates the initial attachment of these cells to high endothelial venules within peripheral lymph nodes. This adhesive interaction is required for the migration of B and T lymphocytes from the blood into peripheral lymph nodes. There is currently little information regarding the nature of the factors involved in the regulation of the synt...

Journal: :Cancer science 2013
Shaohong Chen Zhiqiang Wang Xinzhen Dai Jianhua Pan Juan Ge Xiqun Han Zijing Wu Xinhua Zhou Tong Zhao

Burkitt lymphoma (BL) is a highly aggressive B-cell lymphoma that includes two forms of BL differing in Epstein-Barr virus (EBV) infection status, EBV-positive and EBV-negative. Although many efforts, such as high-intensity, short-duration combination chemotherapy, have been devoted to improving therapy for this rapidly proliferating neoplasm, there are still significant treatment-associated to...

Journal: :iranian journal of allergy, asthma and immunology 0
mahdi fasihi-ramandi applied biotechnology research center, baqiyatallah university of medical sciences, tehran, iran. jafar amani applied microbiology research center, baqiyatallah university of medical sciences, tehran, iran. alihatef salmanian department of agricultural biotechnology, national institute of genetic engineering and biotechnology (nigeb), tehran, iran. seyedmohammad moazzeni immunology department, tarbiat modares university, tehran, iran. kazem ahmadi molecular biology research center, baqiyatallah university of medical sciences, tehran, iran.

the b-cell cd20 antigen is one of the most reliable surface targets in immunotherapy of b lymphoma. in this project, we studied the production and characterization of a new monoclonal antibody against chimeric human cd20 extra loops (hcd20 exl). the results showed that clone c12h, igg2/k isotype reacted with the antigen in elisa and immunoblot. the kd value was  found to be 2×10-9m and flow cyt...

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