In our search for new anticancer medicinal plants, the antiproliferative activity of the methanol extract of Daphne mucronata (Thymelaeaceae) was evaluated using human myelogenous leukemia K562 cells. The cells responded to plant treatments in a dose dependent manner and the IC50 of the crude extract (equivalent to 1 g of plant leaves powder per ml) and the purified active component were found ...

in the framework of a study on the powdery mildew fungi in iran, several infected plant specimens were collected from around the country during 2001-2009. based on the results of the study erysiphe quercicola on quercus sp. and e. malvae on malva sp., golovinomyces ambrosiae on helianthus spp., golovinomyces fischeri on senecio glaucus, are the newly reported for iranian mycobiota. in addition,...

Three new flavanols, 5-p-hydroxybenzoxy-7-hydroxyl-8-ethoxycarbonyl-( - )-afzelechin (1), 5-p-hydroxybenzoxy-7-(2, 3, 5-trihydroxybenzoxy)-8-ethoxycarbonyl-( - )-afzelechin (2), and 5-p-hydroxybenzoxy-7-(2, 3, 5-trihydroxybenzoxy)-8-methoxycarbonyl-( - )-afzelechin (3), were isolated from Daphne giraldii Nitsche and their structures were elucidated by spectroscopic methods, especially by 2D-NMR...

BACKGROUND AND THE PURPOSE OF THE STUDY Gnidilatimonoein (Gn), a new diterpene ester from Daphne mucronata, possesses strong anti-metastasis and anti-tumor activities. In this study, its apoptosis and differentiation capabilities were evaluated by using the leukemia HL-60 cell line. MATERIAL AND METHODS Cell prolifaration inhibition was estimated by MTT assay. The occurrence of apoptosis was ...