background: treatment of ionizing radiation combined with chemical agents can enhance the inactivation of cells. the aim of this study was to determine the parameters involved in the inhibition of cell recovery. materials and methods: a mathematical model describing the process of recovery as a decrease in the effective radiation dose was used. the model includes two parameters, recovery consta...

zno nps (zinc oxide nanoparticles) has generated significant scientific interest as a novel antibacterial and anticancer agent. since oxidative stress is a critical determinant of zno nps-induced damage, it is necessary to characterize their underlying mode of action. different structural and physicochemical properties of zno nps such as particle surface, size, shape, crystal structure, chemica...

Articular cartilage damage is the primary cause of osteoarthritis. Very little literature work focuses on the microstructural damage mechanism of articular cartilage. In this article, a new numerical method that characterizes fluid coupling in particle model is proposed to study the damage mechanism of articular cartilage. Numerical results show that the damage mechanism of articular cartilage ...

OBJECTIVE To investigate potential mechanisms of oxidative DNA damage in a rat model of type 1 diabetes and in murine proximal tubular epithelial cells and primary culture of rat proximal tubular epithelial cells. RESEARCH DESIGN AND METHODS Phosphorylation of Akt and tuberin, 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) levels, and 8-oxoG-DNA glycosylase (OGG1) expression were measured in k...