This study proposes damage detection algorithms for multistory shear structures that only need the first two or three natural frequencies. The methods are able to determine the location and severity of damage on the basis of damage location indices (DLI) and damage quantification indices (DQI) consisting of the changes in the first few squared natural frequencies of the undamaged and damaged st...

The present study was designed to assess whether the orally active and highly specific endothelin A (ET(A)) receptor antagonist LU 135252 affects progressive renal dysfunction in a hypertensive rat model of renal damage, ie, the uninephrectomized (UNX) stroke-prone spontaneously hypertensive rat (SHRsp). The animals were examined on a normal salt (0.25%) diet and, to sensitize the kidney to hyp...

This paper provides a methodology to quantify the interrelationship between the seismic intensity parameters and the structural damage. First, a computer-supported elaboration of the accelerograms provides several peak, spectral and energy seismic parameters. After that, nonlinear dynamic analyses are carried out to provide the structural response for a set of seismic excitations. Among the sev...

Although prospective studies of defibrillator shock overdose cannot be performed in man, the therapeutic indices of various defibrillating current waveforms can be measured in animals. We determined the ratios TD50/ED50 and LD50/ED50 (where TD50 = median "toxic" or damage-inducing dose, ED50 = median effective or defibrillating dose, and LD50 = median lethal dose) as measures of the therapeutic...

This paper presents research documenting the local damage progression in rectangular concrete-filled steel tube beam-columns and connections in composite frames. Local damage is quantified through the development of damage indices based upon results of worldwide experiments. A fiber-based finite element formulation is also introduced for assessing global capacity and seismic demand.