The deformation of rocks is associated with microcracks nucleation and propagation, i.e. damage. The accumulation of damage and its spatial localization lead to the creation of a macroscale discontinuity, a so-called “fault” in geological terms, and to the failure of the material, i.e., a dramatic decrease of the mechanical properties as strength and modulus. The damage process can be studied b...

In this paper, we present a general model for predicting the fatigue behavior for any stress level and amplitude using the exponential model. Based on the W\"ohler field for fixed stress level, a compatibility functional equation enables us to derive the general model with eight parameters. The problem of parameter estimation is then

If aging is understood as some process of damage accumulation, it does not necessarily lead to increasing mortality rate. Within the framework of a suggested generalization of the Strehler-Mildwan (1960) [B.L. Strehler, A.S. Mildvan (1960). General theory of mortality and aging, Science, 132, 14] model, we show that even for models with monotonically increasing degradation, the mortality rate c...

BACKGROUND Gastric carcinogenesis is a multifactorial, multistep process, in which chronic inflammation plays a major role. AIMS In order to ascertain whether free radical mediated oxidative DNA damage is involved in such a process, concentrations of 8-hydroxydeoxyguanosine (8OHdG), a mutagenic/carcinogenic adduct, and thiobarbituric acid reactive substances (TBARS), as an indirect measure of...

Analysis of accumulation of repair and checkpoint proteins at repair sites in yeast nuclei has conventionally used chemical agents, ionizing radiation or induction of endonucleases to inflict localized damage. In addition to these methods, similar studies in mammalian cells have used laser irradiation, which has the advantage that damage is inflicted at a specific nuclear region and at a precis...