INTRODUCTION Aquaporins and ion channels are membrane proteins that facilitate the rapid movement of water and solutes across biological membranes. Experimental and in vitro studies reported that the function of these channels and pulmonary edema resolution are impaired in acute lung injury (ALI). Although current evidence indicates that alveolar fluid clearance is impaired in patients with ALI...

This study sought to identify, by means of several analytical methods (GC-MS, HPLC-DAD, CE-DAD, FTIR, and NMR), 4-bromo-2,5-dimethoxyphenethylamine (2C-B), which was found in two sets of tablets obtained from the Swiss black market. Unequivocal identification of 2C-B was only achieved by a combination of mass spectrometric and NMR analysis. Quantitation of 2C-B was performed by HPLC-DAD and CE-...

Formins are a large family of actin assembly-promoting proteins with many important biological roles. However, it has remained unclear how formins nucleate actin polymerization. All other nucleators are known to recruit actin monomers as a central part of their mechanisms. However, the actin-nucleating FH2 domain of formins lacks appreciable affinity for monomeric actin. Here, we found that yea...

BACKGROUND Although diffuse alveolar damage (DAD) is considered the typical histological pattern of acute respiratory distress syndrome (ARDS), only half of patients exhibit this morphological hallmark. Patients with DAD may have higher mortality than those without DAD. Therefore, we aimed to identify the factors associated with DAD in patients with ARDS. METHODS We analyzed autopsy samples o...

OBJECTIVE Despite prevention efforts, driving after drinking (DAD) is a prevalent high-risk behavior among college students and is a leading cause of death and injury. Examination of factors predicting future DAD behavior is necessary to develop efficacious targeted interventions to reduce this behavior among college students. The current study evaluated demographic, social cognitive, and behav...

Seminomas and nonseminomas represent the invasive stages of testicular (TGCTs) of adolescents and adults. Although TGCTs are characterized by extra copies of the short arm of chromosome 12, the genetic basis for gain of 12p in the pathogenesis of this cancer is not yet understood. We have demonstrated that gain of 12p is related to invasive growth and that amplification of specific 12p sequence...

Context: Distributed agile development (DAD) approach has been adopted by the software companies for cost and time benefits. However, it causes significant challenges considering the contradicting nature of the agile and distributed development. Objective: The objective of this study is to develop a risk management framework that comprises the perceived risks in DAD projects, their causes and t...

In Mobile IPv6 especially in Hierarchical Mobile IPv6 (HMIPv6), Mobile Node’s handoff performance is greatly impaired by the Duplicate Address Detection (DAD) procedure for the newly formed Care-of Address. Based on the data gathered from our HMIPv6 test bed, this paper analyzed the origin of such performance degradation. To alleviate the impact of DAD on handoff performance, Greg Daley et al p...

Ss who receive information about a person's traits and behaviors in a social context are likely to focus their attention on the pragmatic implications of this information (i.e., why the information was conveyed). To examine this hypothesis, Ss listened to a taped conversation in which a male target (T) and another speaker (O) exchanged anecdotal accounts of T's behavior. Ss typically used O's t...