Vascular cell adhesion molecule-1 (VCAM-1) is closely associated with tumor progression and metastasis. However, the relevance and role of VCAM-1 in lung cancer have not been clearly elucidated. In this study, we found that VCAM-1 was highly overexpressed in lung cancer tissue compared with that of normal lung tissue, and high VCAM-1 expression correlated with poor survival in lung cancer patie...

VCAM-1 plays a key role in leukocyte trafficking during inflammatory responses. However, molecular mechanisms underlying this function have not been clearly elucidated. In this study, using phage display technology, we developed a rabbit/human chimeric VCAM-1 Ab, termed VCAM-1 domain 6 (VCAM-1-D6), which specifically recognizes aa 511-599 within the sixth Ig-like domain. We report that the VCAM...

Abstract Background High-quality single blastocyst transfer (SBT) is increasingly recommended to patients because of its acceptable pregnancy outcomes and significantly reduced multiple rate compared double (DBT). However, there no consensus on whether this strategy also suitable for poor-quality blastocysts. Moreover, the effect development speed blastocysts has been controversial. Therefore, ...

We study a family of BPS solutions of type IIA supergravity that can be interpreted as describing the ‘transmutation’ of a Neveu-Schwarz five-brane into a D4-brane in the presence of a D6-brane. The D4-brane, which terminates on the D6-brane, can be equally well interpreted as a ‘pure multipole’ configuration of NS5-brane wrapped tightly around the D6-brane. Such a transmutation is a “near-core...

Selective sequestration of inflammatory chemokines is critical for the successful resolution of inflammatory responses in vivo. D6 is an atypical chemokine receptor that scavenges inflammatory chemokines and is pivotal in resolving models of chemokine-driven cutaneous inflammation. We provide evidence that expression of D6 is not limited to the lymphatic endothelium at sites of inflammation as ...

D6 is a decoy and scavenger receptor for inflammatory CC chemokines. D6-deficient mice were rapidly killed by intranasal administration of low doses of Mycobacterium tuberculosis. The death of D6(-/-) mice was associated with a dramatic local and systemic inflammatory response with levels of M. tuberculosis colony-forming units similar to control D6-proficient mice. D6-deficient mice showed an ...

BACKGROUND Pre-eclampsia (PE) is a major cause of maternal and perinatal morbidity and mortality worldwide. It is defined by new onset of hypertension and proteinuria after the 20th week of gestation and characterized by systemic exaggerated inflammatory response. D6 is a chemokines scavenger receptor that binds with high affinity CC chemokines, internalizes and targets the ligands for degradat...

BACKGROUND Bisphenol A (BPA) is a widely produced endocrine-disrupting chemical. Diet is a primary route of exposure, but internal exposure (serum concentrations) in animals and humans has been measured only after single oral bolus administration. OBJECTIVE We compared serum concentrations of BPA over a 24-hr period after oral bolus administration or ad libitum feeding in mice and assessed fo...

In this paper we study the gravitational dielectric phenomena of a D2-brane in the background of Kaluza-Klein monopoles and D6-branes. In both cases the spherical D2-brane with nonzero radius becomes classical solution of the D2-brane action. We also investigate the gravitational Myers effect in the background of D6-branes. This phenomenon occurs since the tension of the D2-brane balances with ...