BACKGROUND To investigate different responses to a high-fat/cholesterol diet and uncover their underlying genetic factors between C57BL/6J (B6) and DBA/2J (D2) inbred mice. METHODS B6 and D2 mice were fed a high-fat/cholesterol diet for a series of time-points. Serum and bile lipid profiles, bile acid yields, hepatic apoptosis, gallstones and atherosclerosis formation were measured. Furthermo...

p97, an essential chaperone in endoplasmic reticulum-associated degradation and organelle biogenesis, contains two AAA domains (D1 and D2) and assembles as a stable hexamer. We present a quantitative analysis of nucleotide binding to both D1 and D2 domains of p97, the first detailed study of nucleotide binding to both AAA domains for this type of AAA+ ATPase. We report that adenosine 5'-O-(thio...

Although the dopamine D1-D2 receptor heteromer has emerging physiological relevance and a postulated role in different neuropsychiatric disorders, such as drug addiction, depression, and schizophrenia, there is a need for pharmacological tools that selectively target such receptor complexes in order to analyze their biological and pathophysiological functions. Since no selective antagonists for...

We identified the presence of iodothyronine deiodinase in AtT-20 mouse pituitary tumor cells that secrete corticotropin. Iodothyronine deiodinating activity in AtT-20 cells fulfills all the characteristics of type 2 iodothyronine deiodinase (D2), including the inhibition by thyroid hormones, the insensitivity to inhibition by 6-propyl-2-thiouracil, and the low Michaelis-Menten constant value fo...

The correlation dimension (D2) is a mathematical tool that quantifies dimensional properties of fractals. We set out to determine whether immunoglobulin light chain restriction (LCR) in B-cell lymphoproliferative disorders (BCLPDs) could be identified using the D2. The D2 was calculated from flow cytometry data files (FCS 2.0) from a training set of peripheral blood specimens from 22 patients w...

We show that the decay of the D2-D2 system with large worldvolume magnetic fields can be described in noncommutative gauge theory. Tachyon condensation in this system describes the annihilation of D2-D2 into D0-branes. From the 2 + 1 dimensional point of view, this is the decay of a nonabelian magnetic flux into vortices. The semiclassical approximation is valid over a long period of the decay....

...................................................................................................................... iv INTRODUCTION ...............................................................................................................1 DOPAMINERGIC PATHWAYS............................................................................1 BASAL GANGLIA .......................................

Due to the higher hydrogen solubility and diffusivity, gadolinium sesquioxide (Gd2O3) could be expected as a proton conductive material. In this study, monoclinic Gd2O3 was used evaluate possible conductivity in Ar (?Ar), Ar+4% H2 (?H2), D2 (?D2), Ar+H2O (?H2O), Ar+D2O (?D2O), O2 (?O2) atmospheres temperature range from 500°C 1000°C, understand its application DT fuel system of nuclear fusion r...

The C3H/HeJ mouse presents an inherited type 1 deiodinase (D1) deficiency that results in elevated serum thyroxine (T(4)), whereas TSH and tri-iodothyronine (T(3)) concentrations are normal when compared with those in the C57BL/6J strain. Here, we evaluated the expression of the type 2 (D2), the other T(4)-activating enzyme, in C3H mice. A comparative analysis revealed that D2 mRNA levels in C3...