In LTK- cells stably transfected with rat D1A receptor cDNA, fenoldopam, a D1 agonist, increased phosphatidylinositol 4, 5-bisphosphate hydrolysis in a time-dependent manner. In the cytosol, phospholipase C (PLC) activity increased (50 +/- 7%) in 30 s, returned to basal level at 4 h, and decreased below basal values by 24 h; in the membrane, PLC activity also increased (36 +/- 13%) in 30 s, ret...

Mutualistic organisms can be particularly susceptible to climate change stress, as their survivorship is often limited by the most vulnerable partner. However, symbiotic plasticity can also help organisms in changing environments by expanding their realized niche space. Coral-algal (Symbiodinium spp.) symbiosis exemplifies this dichotomy: the partnership is highly susceptible to 'bleaching' (st...

nloaded DNA damage response (DDR) activates downstream pathways including cell cycle checkpoints. The D1 gene is overexpressed or amplified in many human cancers and is required for gastrointestinal, , and skin tumors in murine models. A common polymorphism in the human cyclin D1 gene is atively spliced, resulting in cyclin D1a and D1b proteins that differ in their carboxyl terminus. Cyclin ere...

Downlo DNA damage response (DDR) activates downstream pathways including cell cycle checkpoints. The D1 gene is overexpressed or amplified in many human cancers and is required for gastrointestinal, , and skin tumors in murine models. A common polymorphism in the human cyclin D1 gene is atively spliced, resulting in cyclin D1a and D1b proteins that differ in their carboxyl terminus. Cyclin erex...

Downlo DNA damage response (DDR) activates downstream pathways including cell cycle checkpoints. The D1 gene is overexpressed or amplified in many human cancers and is required for gastrointestinal, , and skin tumors in murine models. A common polymorphism in the human cyclin D1 gene is atively spliced, resulting in cyclin D1a and D1b proteins that differ in their carboxyl terminus. Cyclin erex...

Coral bleaching involves the loss of symbiotic algae (zooxanthellae) from reef corals and other cnidarians during periods of environmental stress, particularly elevated temperature. In this study we compared the thermal bleaching responses of the zoanthid Palythoa caribaeorum from three populations along the southeast coast of Florida. Winter (2002–2003) and summer (2003) samples from three geo...

Decisions are often driven by a combination of immediate perception and previous experience. In this study, we investigated how these two sources of information are integrated and the neural systems that mediate this process. Specifically, we injected a dopamine type 1 antagonist (D1A; SCH23390) or a dopamine type 2 antagonist (D2A; eticlopride) into the dorsal striatum while macaques performed...