We propose and develop a genetic algorithm (GA) for generating D-optimal designs where the experimental region is an irregularly shaped polyhedral region. Our approach does not require selection of points from a user-defined candidate set of mixtures and allows movement through a continuous region that includes highly constrained mixture regions. This approach is useful in situations where extr...

Food fortification is an effective intervention strategy for combating micronutrient deficiencies. Vitamin A can be fortified in a wide range of food vehicles. In this research work, vitamin the form palmitate (VAP) have been microencapsulated by emulsion technology intended purposes. D-optimal mixture design approach was applied optimizing experimental process parameters. Detailed physico-chem...

Nanoemulsions are alternative means of incorporating functional components into systems. This research aims to model the effect African catfish mucilage (ACM) concentrations on particle size (PS) stable oil-in-water (O/W) nanoemulsions formulated by ultrasonication. A D-optimal mixture design was used study influence three (MCs) ACM, oil, and water PS. Morphology PS were determined with Cryo-TE...

Consider a Bayesian optimal design with many support points which poses the problem of collecting data with a few number of observations at each design point. Under such a scenario the asymptotic property of using Fisher information matrix for approximating the covariance matrix of posterior ML estimators might be doubtful. We suggest to use Bhattcharyya matrix in deriving the information matri...