نتایج جستجو برای: cytome assay

تعداد نتایج: 221732  

Journal: :Mutagenesis 2011
Lucia Migliore Fabio Coppedè Michael Fenech Philip Thomas

Micronuclei (MNi) can originate either from chromosome breakage or chromosome malsegregation events and are therefore ideal biomarkers to investigate genomic instability. Studies in peripheral lymphocytes of patients with neurodegenerative diseases, mainly Alzheimer's disease (AD) and Parkinson's disease (PD), revealed an increased micronucleus (MN) frequency in both disorders but originating m...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007
Bianca Benassi Richard Leleu Tony Bird Peter Clifton Michael Fenech

We tested the cytokinesis-block micronucleus cytome assay using the WIL2-NS human B lymphoblastoid cell line as a biomarker of genotoxicity and cytotoxicity of cecal water from rats and fecal water from humans. Cecal water was assessed in rats fed either a diet rich in fat, low in calcium and fiber, and barbecued red meat as the protein source (high colorectal cancer risk diet) or a diet high i...

2011
Pengpeng Liu Rongfa Guan Xingqian Ye C Hirsch J-P Kaiser F Wessling K Fischer M Roesslein P Wick

The amount of engineered nanomaterials (ENM) is constantly increasing. Their unique properties, compared to their bulk counterparts, render them suitable for various applications in many areas of life. Hence, nanomaterials appear in a variety of different consumer products leading to the exposure of human beings and the environment during their lifecycle. Even though results on biological effec...

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