Thyroid hormones enhance aerobic metabolism favoring oxidative stress which may lead to covalent damage of various molecules including DNA. Previous investigations revealed that thyroid hormones induce DNA damage on human lymphocytes and sperm in the in vitro Comet assay. However, cytogenetic evaluation of genotoxic effects of thyroxine gave equivocal results: increase of sister chromatid excha...

Estimating the effects of small doses of ionising radiation on DNA is one of the most important problems in modern biology. Different cytogenetic methods exist to analyse DNA damage; the cytokinesis-block micronucleus assay (CBMN) for human peripheral blood lymphocytes is a simple, cheap and informative cytogenetic method that can be used to detect genotoxic-related markers. With respect to pre...

Aim. The main goal of this study was to the anti-radiation effect guaninium-zinc chloride complex on cytogenetic changes in irradiated rats. Methods. White rats Wistar line with an average weight 110-125 grams served as material for detection complex. Animals were injected intraperitoneally solutions at a concentration 40 mg/kg 2 hours before irradiation and subjected general uniform gamma from...

Background: Acute lymphoblastic leukemia (ALL) is the sixth most common malignancy in Iran. Cytogenetic analysis of leukemic blasts plays an important role in classification and prognosis in ALL patients. The purpose of this study was to define the frequency of chromosomal abnormalities of ALL patients in adults and children in Fars province, Iran.Methods: In this cross-sectional study, we eval...