Introduction. Peritoneal mesothelioma is a rare tumor, presenting difficulties in diagnosis and treatment. Peritoneum is the second most common area of the mesothelioma after pleura, and even synchronous pleural and peritoneal mesotheliomas are observed in 30-45% of all cases. The diagnosis may be difficult due to lack of specific symptoms and clinical findings. In addition, a delay in the diag...

Most gene expression profiling studies of mesothelioma have been based on relatively small sample numbers, limiting their statistical power. We did Affymetrix U133A microarray analysis on 99 pleural mesotheliomas, in which multivariate analysis showed advanced-stage, sarcomatous histology and P16/CDKN2A homozygous deletion to be significant independent adverse prognostic factors. Comparison of ...

Nine malignant mesotheliomas and 12 specimens of benign reactive mesothelial hyperplasia were examined using a specific antimesothelial cell antibody. Immunostaining intensity was subsequently estimated by means of image analysis. The mean and standard deviation of integrated optical density in the malignant mesotheliomas differed significantly from those in the mesothelial hyperplasias. In all...

Cystic tumours of the atrioventricular node (sometimes called ‘‘benign mesotheliomas of the atrioventricular node’’) are rare lesions associated with sudden cardiac death. 2 A recent case provided several informative points regarding the nature of this lesion and best practice methodology within the coroner’s necropsy. A 31 year old man, training for a marathon, collapsed and died suddenly with...

M alignant mesotheliomas of the pleural and peritoneal cavity have long been recognized as tumors unique in man. They were first described before the turn of the century although their causation at that time was totally obscure. Now, we are aware that a substantial proportion of the mesotheliomas occurring in the Western world result from exposure to amphibole asbestos. In this brief survey, I ...

Mesotheliomas are tumors of low grade malignancy originating from mesothelial cells covering the coelomic cavities such as pericardium, pleura, peritoneum and vaginal tunic (Seo et al., 2007). The three types mesotheliomas epithelial, fibrous (arcomatous) biphasic (mixed). epithelial form, which closely resembles carcinoma adenocarcinoma, is most common type mesothelioma in dogs (Echandi Pleura...

CD9 is involved in cell growth, adhesion and motility and its expression is reported to be of prognostic significance in various types of human malignancies. We found increased cell migration in the mesothelioma cell lines MSTO-211H and TUM1 following in vitro shRNA-mediated knockdown of CD9 expression. We investigated CD9 expression in 112 malignant pleural mesotheliomas. CD9 expression was ob...

A majority (∼80%) of human malignant mesotheliomas are asbestos-related. However, non-asbestos risk factors (radiation, chemicals, and genetic factors) account for up to 30% of cases. A recent 2-year National Toxicology Program carcinogenicity bioassay showed that male F344/N rats exposed to the industrial toxicant vinylidene chloride (VDC) resulted in a marked increase in malignant mesotheliom...