نتایج جستجو برای: cystatin c

تعداد نتایج: 1057234  

2017
Anders Grubb

The present minireview of the place of cystatin C in clinical medicine emphasizes, and discuss the evidence, that cystatin C-based GFR-estimating equations do not require the use of vague terms like race and sex, that cystatin C-based GFR-esti mating equations are useful for both children and adults, including the elderly, that the best GFR-estimation requires simultaneous use of both cystatin ...

Journal: :The Journal of biological chemistry 1999
M Alvarez-Fernandez A J Barrett B Gerhartz P M Dando J Ni M Abrahamson

We have investigated the inhibition of the recently identified family C13 cysteine peptidase, pig legumain, by human cystatin C. The cystatin was seen to inhibit enzyme activity by stoichiometric 1:1 binding in competition with substrate. The Ki value for the interaction was 0.20 nM, i.e. cystatin C had an affinity for legumain similar to that for the papain-like family C1 cysteine peptidase, c...

Journal: :iranian journal of medical sciences 0
farid zand shiraz anesthesiology and critical care research center, shiraz university of medical sciences, shiraz, iran golnar sabetian trauma research center, shiraz university of medical sciences, shiraz, iran ghasem abbasi department of anesthesia, school of medicine, shiraz university of medical sciences, shiraz, iran abbas rezaianzadeh department of epidemiology, school of medicine, shiraz university of medical sciences, shiraz, iran alireza salehi research center in traditional medicine and history of medicine, shiraz university of medical sciences, shiraz, iran abbas khosravi trauma research center, shiraz university of medical sciences, shiraz, iran

background: acute kidney injury (aki) is a common problem in critically ill patients and is independently associated with increased morbidity and mortality. recently, serum cystatin c has been shown to be superior to creatinine in early detection of renal function impairment. we compared estimated gfr based on serum cystatin c with estimated gfr based on serum creatinine for early detection of ...

Journal: :acta medica iranica 0
hooshang amir rasouli department of radiotherapy-oncology, imam hossein hospital, shahid beheshti university of medical sciences, tehran, iran. maryam mirzaie moghadam department of radiotherapy-oncology, imam hossein hospital, shahid beheshti university of medical sciences, tehran, iran. morteza tabatabaiefar department of radiotherapy-oncology, imam hossein hospital, shahid beheshti university of medical sciences, tehran, iran. farnaz taslimi department of radiotherapy-oncology, imam hossein hospital, shahid beheshti university of medical sciences, tehran, iran. khosro mojir sheybani department of radiotherapy-oncology, imam hossein hospital, shahid beheshti university of medical sciences, tehran, iran. asadollah alidoosti department of radiotherapy-oncology, imam hossein hospital, shahid beheshti university of medical sciences, tehran, iran.

the objective of this study was to determine and compare cystatin c changes before and after radiotherapy in patients with stomach cancer who were candidate for radiotherapy. this study was conducted as a prospective cohort one. eighteen patients with definite diagnosis of stomach cancer under treatment by radiotherapy who presented to radiotherapy-oncology center of imam hossein hospital, tehr...

2009
Barbara Wegiel Thomas Jiborn Magnus Abrahamson Leszek Helczynski Leo Otterbein Jenny Liao Persson Anders Bjartell

Cystatin C is believed to prevent tumor progression by inhibiting the activities of a family of lysosomal cysteine proteases. However, little is known about the precise mechanism of cystatin C function in prostate cancer. In the present study, we examined the expression of cystatin C and its association with matrix metalloproteinases 2 (MMP2) and androgen receptor (AR) in a tissue microarray co...

2014
P. Srilakshmi Vijaya Bhaskar K. Rambabu M. F. Gopinath Srinivasa Reddy

Cystatin C, an established marker of renal dysfunction, is gaining importance in dysfunction of other organs (systems) as well. Preliminary studies indicated a role for cystatin C as a prognostic marker in coronary artery disease (CAD). The aim of the study was to assess the of serum cystatin C levels in CAD cases and its comparison with controls. Comparison of serum cystatin C levels in CAD sp...

Journal: :European heart journal 2007
Johan Lassus Veli-Pekka Harjola Reijo Sund Krista Siirilä-Waris John Melin Keijo Peuhkurinen Kari Pulkki Markku S Nieminen

AIMS Cystatin C, a novel marker of renal function, has been implicated as a prognostic marker in cardiovascular disease. We investigated the prognostic value of cystatin C in acute heart failure (AHF) in comparison to other markers of renal function and NT-proBNP. METHODS AND RESULTS Patients with cystatin C measurements (n = 480) from a prospective multicentre study on AHF were included. All...

Journal: :The Biochemical journal 1998
B Asgeirsson S Haebel L Thorsteinsson E Helgason K O Gudmundsson G Gudmundsson P Roepstorff

Hereditary cystatin C amyloid angiopathy (HCCAA) is an autosomal dominant condition in which the patients suffer at an early age from repeated cerebral haemorrhages. The development of HCCAA is directly linked to a Leu-68-->Gln (L68Q) mutation in the cystatin C protein sequence. The concentration of cystatin C in cerebrospinal fluid (CSF) of HCCAA patients is markedly diminished and cultivated ...

Journal: :medical laboratory journal 0
marjan vahedi islamic azad university , sari, iran parvin farzanegi sari branch, , islamic azad university , sari, iran

abstract       background and objectives: diabetes induced oxidative stress plays an important role in pathological damage to the heart and liver by increased production of extracellular matrix. it is thought that the use of medicinal plants, particularly portulaca oleracea. l and regular exercise are effective. the aim of this study was to evaluate the effects of portulaca oleracea. l consumpt...

Journal: :Journal of dental research 1999
T R Hiltke T C Lee L A Bobek

Cystatins are reversible, competitive inhibitors of cysteine proteinases. Their inhibitory profiles, as well as their affinities for target enzymes, vary with different cysteine proteinases. Human cystatin C and salivary cystatin SN are 120- and 121-amino-acid (a.a.) proteins, respectively, and both contain 2 disulfide bonds. In this study, we examined the structure/function relationship of cys...

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