Mitochondrial mechanism of oxidative stress and matrix metalloproteinase (MMP) activation was unclear. Our recent data suggested that MMPs are localized to mitochondria and activated by peroxynitrite, which causes cardiovascular remodeling and failure. Recently, we have demonstrated that elevated levels of homocysteine (Hcy), known as hyperhomocysteinemia (HHcy) increase oxidative stress in the...

gases such as no and co play important roles both in normal physiology and in disease. in recent years, interest has been directed towards other naturally occurring gases, notably h 2 s, which is produced in body by three enzymes namely cbs (cystathionine beta synthase), cse (cystathionine gamma lyase) and mst (3-mercaptopyruvate sulfurtransferase), present in mitochondria and/or cytosols where...

Annotation. Vitamin D and hydrogen sulfide (H2S) belong to pleitropic regulators, which are involved in the control of many cellular functions biochemical processes, determine adaptive potential cardiovascular system. The relationship between vitamin H2S system is not fully investigated. aim study was evaluate effect active form - calcitriol (1,25 (OH)2D3) on morphological state thoracic aorta ...

Accumulating evidence shows that H2S has physiological functions in various tissues and organs. It includes regulation of neuronal activity, vascular tension, a release of insulin, and protection of the heart, kidney, and brain from ischemic insult. H2S is produced by enzymes from l-cysteine; cystathionine β-synthase, cystathionine γ-lyase, and 3-mercaptopyruvate sulfurtransferase (3MST) along ...

O2 chemoreceptors elicit cardiorespiratory reflexes in all vertebrates, but consensus on O2-sensing signal transduction mechanism(s) is lacking. We recently proposed that hydrogen sulfide (H2S) metabolism is involved in O2 sensing in vascular smooth muscle. Here, we examined the possibility that H2S is an O2 sensor in trout chemoreceptors where the first pair of gills is a primary site of aquat...

Hydrogen sulfide (H2S) is a familiar toxic gas that smells of rotten eggs. After the identification of endogenous H2S in the mammalian brain two decades ago, studies of this molecule uncovered physiological roles in processes such as neuromodulation, vascular tone regulation, cytoprotection against oxidative stress, angiogenesis, anti-inflammation, and oxygen sensing. Enzymes that produce H2S, ...

Aims. To examine whether hydrogen sulfide (H2S) generation changed in ageing diabetic mouse hearts. Results. Compared to mice that were fed tap water only, mice that were fed 30% fructose solution for 15 months exhibited typical characteristics of a severe diabetic phenotype with cardiac hypertrophy, fibrosis, and dysfunction. H2S levels in plasma, heart tissues, and urine were significantly re...

Gases such as NO and CO play important roles both in normal physiology and in disease. In recent years, interest has been directed towards other naturally occurring gases, notably H 2 S, which is produced in body by three enzymes namely CBS (cystathionine beta synthase), CSE (cystathionine gamma lyase) and MST (3-Mercaptopyruvate sulfurtransferase), present in mitochondria and/or cytosols where...

Hydrogen sulfide (H2S) is a recently identified gasotransmitter that may mediate hypoxic responses in vascular smooth muscle. H2S also appears to be a signaling molecule in mammalian non-vascular smooth muscle, but its existence and function in non-mammalian non-vascular smooth muscle have not been examined. In the present study we examined H2S production and its physiological effects in urinar...