نتایج جستجو برای: cyp enzyme

تعداد نتایج: 243651  

Journal: :Cancer research 1996
T M Buetler T K Bammler J D Hayes D L Eaton

Oltipraz (OPZ) is currently being considered for human use to protect against aflatoxin B1 (AFB)-induced hepatocarcinogenesis based on its proven protective effect in rats. The effectiveness of this treatment presumes that orthologous cytochrome P450 and glutathione S-transferase (GST) isozymes metabolize AFB in humans as they do in rats. In this study, alterations in the expression of multiple...

Journal: :SpringerPlus 2016
Krystina Parker Willy Aasebø Tore Haslemo Knut Stavem

BACKGROUND Elderly patients on haemodialysis have a high prevalence of polypharmacy and are at risk of drug-related complications. More than 80 % of all prescribed drugs are metabolized by the cytochrome P450 (CYP) enzyme system. The aims of this study were to describe the prevalence of polymorphism in three CYP isoenzymes and the relationship between CYP polymorphism and prescribed drugs. ME...

2013
Charles L. Crespi

Oxidative drug metabolism via the cytochrome P450 (CYP) system is a principle means of drug clearance. Several decades of studies have pointed to five CYP forms—CYP1A2, 2C9, 2C19, 2D6, and 3A—as those which are primarily responsible for human metabolism of small molecule (MW <1500) drugs and drug-like compounds.1 The absolute levels and CYP enzyme activities vary substantially among individual ...

Journal: :Journal of inorganic biochemistry 2008
Yoshitomo Hamuro Kathleen S Molnar Stephen J Coales Bo OuYang Alana K Simorellis Thomas C Pochapsky

Backbone dynamics of the camphor monoxygenase cytochrome P450(cam) (CYP101) as a function of oxidation/ligation state of the heme iron were investigated via hydrogen/deuterium exchange (H/D exchange) as monitored by mass spectrometry. Main chain amide NH hydrogens can exchange readily with solvent and the rate of this exchange depends upon, among other things, dynamic fluctuations in local stru...

Journal: :Carcinogenesis 2006
Henry P Ciolino Christopher J MacDonald Omar S Memon Sara E Bass Grace Chao Yeh

Sulindac, a widely used non-steroidal anti-inflammatory drug (NSAID), has been shown to inhibit chemically induced carcinogenesis in animal models. In the present study, we have investigated the molecular mechanism by which sulindac affects the activity and expression of the enzymes that mediate the initial detoxification steps of many environmental carcinogens, the cytochromes P450 1A1, 1A2 an...

2012
Kwon-Young Choi EunOk Jung Da-Hye Jung Byeo-Ri An Bishnu Prasad Pandey Hyungdon Yun Changmin Sung Hyung-Yeon Park Byung-Gee Kim

A cytochrome P450 (CYP) enzyme, 3'-daidzein hydroxylase, CYP105D7 (3'-DH), responsible for daidzein hydroxylation at the 3'-position, was recently reported. CYP105D7 (3'-DH) is a class I type of CYP that requires electrons provided through electron transfer proteins such as ferredoxin and ferredoxin reductase. Presently, we constructed an artificial CYP in order to develop a reaction host for t...

Journal: :Molecules 2016
Shaheed Ur Rehman Min Sun Choi In Sook Kim Zengwei Luo Yongbo Xue Guangming Yao Yonghui Zhang Hye Hyun Yoo

Kinsenoside, the herb-derived medicine isolated from the plant Anoect chilus, has diverse pharmacological actions, and it is considered to be a promising antihyperlipidemic drug candidate. This study evaluates the effects of kinsenoside on CYP enzyme-mediated drug metabolism in order to predict the potential for kinsenoside-drug interactions. Kinsenoside was tested at different concentrations o...

Journal: :Archives of biochemistry and biophysics 2003
Alex Baldwin Zeqi Huang Youssef Jounaidi David J Waxman

Gene-directed enzyme prodrug therapy can be used to increase the therapeutic activity of anti-cancer prodrugs that undergo liver cytochrome P450 (CYP)-catalyzed prodrug to active drug conversion. The present report describes a cell-culture-based assay to identify CYP gene-CYP prodrug combinations that generate bystander cytotoxic metabolites and that may potentially be useful for CYP-based gene...

Journal: :Revista medica de Chile 2004
Myriam Orellana Viviana Guajardo

Cytochrome P450 (CYP) enzymes participate in the metabolism of a variety of naturally occurring and foreign compounds by reactions requiring NADPH and O2. The diversity of reactions catalyzed and its extensive substrate specificity render CYP enzymes as one of the most versatile known catalysts. Individual members of the CYP superfamily are expressed in almost every cell type in the body. As co...

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