The aim of this study was to evaluate the prophylactic potential of hyperbaric oxygenation treatment and the timing of hyperbaric oxygen (HBO2) therapy for cyclophosphamide-(CYP) induced cystitis in rats. Forty male Sprague-Dawley rats were divided into 5 groups. Four groups received a single dose of CYP (100 mg/kg.) intraperitoneally (i.p.) at the same time (group 1 served as the control). Gro...

Background The omega-3 fatty acid (ω-3 fatty acid) such as eicosapentaenoic acid (EPA) is currently used in the clinic as a nutritional supplement in the treatment of polycystic ovarian syndrome (PCOS). The present study was designed to investigate the effect of EPA on the expression levels of peroxisome proliferator-activated receptor gamma (PPARγ) and cytochrome P450 aromatase (encoded by the...

Objective: To study the effect of sodium sulfadimethylpyrimidine (SDMP) on different forms of CYP 450 enzymes induced by phenobarbital (CYP 2B1, 2B2 and 3A), isoniazid (CYP 2E1), benzo(a)pyrene (CYP 1A1), clotrimazole (CYP 3A), and clofibrate (CYP 4A). Materials and Methods: Chickens (Hubbard, male) weighing 250–300 g were divided into 17 groups of six each. Five experimental sets were prepared...

We explore racial inequality in relation to Black children and young people (CYP) Child Adolescent Mental Health Services (CAMHS). argue that the experience of racism should be universally considered an Adverse Childhood Experience (ACE). vicarious trauma arising from exposure frequent media reports racially motivated violence against persons ethnicity can all predispose CYP increased risk ment...

Rat was used to characterize Chinese Yam polysaccharides (CYPs). In Exp. 1, maximum volume and rate of gas production in CYP 3-supplemented group were higher than other CYP-supplemented groups and control group, while pH values and NH3 contents in CYP 2-, CYP 3-, and CYP 4-supplemented groups were lower than control group. Contents of acetate, propionate and butyrate increased by supplementing ...

Drug metabolism mostly occurs in the liver. Cytochrome P450 (CYP) is a drug-metabolizing enzyme that is responsible for many important drug metabolism reactions. Recently, the US FDA and EU EMA have suggested that CYP enzyme induction can be measured by both enzymatic activity and mRNA expression. However, these experiments are time-consuming and their inter-assay variability can lead to misint...

The neighbourhoods of cytochrome P450 (CYP) genes in deuterostome genomes, as well as those of the cnidarians Nematostella vectensis and Acropora digitifera and the placozoan Trichoplax adhaerens were examined to find clues concerning the evolution of CYP genes in animals. CYP genes created by the 2R whole genome duplications in chordates have been identified. Both microsynteny and macrosynteny...

1,2-Dichloro-3,3,4,4,5,5-hexafluorocyclopentene (F 6 cypCl 2 ) was functionalized with diphenyl- and dimesitylphosphanyl groups by a salt-elimination reaction of the respecttive chlorophosphane (PPh Cl, PMes Cl) in situ generated lithiated F cyp(Li)Cl. cyp(PR )Cl (R = Ph, Mes) functionalised again to obtain corresponding trimethylstannyl substituted compounds )(SnMe 3 Mes). These tin-precursors...

Genetically engineered bacterial cells expressing human cytochrome P450 (CYP) have been developed as new tools to predict the metabolism and toxicity of drugs in humans. There are various host cells for the heterologous expression of a form of CYP. Among them, bacterial cells such as Escherichia coli (E. coli) have advantages with regard to ease of use and high yield of protein. CYP protein cou...