نتایج جستجو برای: cyclosporins metabolites
تعداد نتایج: 59142 فیلتر نتایج به سال:
Six individuals with Ullrich congenital muscular dystrophy (UCMD) and mutations in the genes-encoding collagen VI, aging 5-9, received 3-5 mg/kg of cyclosporine A (CsA) daily for 1 to 3.2 years. The primary outcome measure was the muscle strength evaluated with a myometer and expressed as megalimbs. The megalimbs score showed significant improvement (P = 0.01) in 5 of the 6 patients. Motor func...
The editors of Metabolites would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2016. [...].
solid phase extraction (spe) cartridge embedded with octadecyl c18 chain bounded to silica particles were used for the isolation and trace enrichment of pesticides from water samples collected from cotton, rice growing and municipal areas. the eluents were analyzed with high performance liquid chromatography (hplc) using methanol (100%) as mobiles phase at different uv-visible wavelengths. ddt ...
Antimicrobial peptides include a diverse array of both natural and synthetic molecules varying greatly in size, charge, hydrophobicity and secondary-structural features. Although better known as antibacterial agents, many peptides have demonstrated activity against the malarial parasite Plasmodium either in its vertebrate blood stages or mosquito stages or both. The antimalarial peptides review...
Drug-free whole-blood samples supplemented with the cyclosporines and samples from 10 transplant patients receiving cyclosporin A (CsA) were equilibrated at 4, 22, and 37 degrees C for 2.5 h; the plasma and cells were separated; and the fractions were assayed by high-performance liquid chromatography (HPLC). Partitioning of CsA and metabolites among plasma and cells was diverse and not always p...
It is quite evident that microbial (bacteria or fungi) crude extracts contain several important bioactive compounds and some have already shown their therapeutic activity. Unfortunately, most of the compounds have not properly been evaluated for the exploration of new lead molecule. Moreover, some of the mechanisms of actions of few bioactive compounds have not been identified so far. Hence, ex...
a sensitive and rapid method is described for determination of clopidogrel carboxylic acid (cca), the inactive metabolite of the antiplatelet agent clopidogrel in human serum. the analytical procedure involves liquid-liquid extraction of the analyte and an internal standard (phenytoin) with ethyl acetate. a mobile phase consisting of 0.05 m phosphate buffer containing triethylamine (0.5 ml/l; p...
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