Flunixin meglumine and meloxicam are non-steroidal anti-inflammatory drug (NSAID). Flunixin meglumine is classified as a carboxylic acid. Its mechanism of action is believed to be primarily via the inhibition of cyclooxygenase (COX) enzymes. This inhibition results in decreased formation of cyclooxygenase-derived eicosanoids involved in the pathophysiology of inflammation, such as thromboxanes ...

Aspirin inhibits platelet function by permanently acetylating the cyclooxygenase that forms prostaglandins. We determined the sensitivity of platelets to aspirin in normal subjects by measuring [3H-acetyl]aspirin-susceptible cyclooxygenase in washed platelets obtained at various times after aspirin ingestion. A single 325-mg aspirin dose inactivated 89% of platelet cyclooxygenase. The inhibitio...

Objective: Inflammation plays a crucial role in the progression of many diseases, excessive inflammation increases immune cell activation, which can destroy tissues and body health. When occurs, multiple pro-inflammatory mediators are overproduced, leading to variety diseases such as rheumatism, diabetes, cardiovascular problems. Brucea javanica has been used traditional medicine therapy for an...