Dynamic alterations in cell surface glycosylation occur in numerous biological processes that involve cell-cell communication and cell migration. We report here imaging of cell surface glycosylation in live mice using double click chemistry. Cell surface glycans were metabolically labeled using peracetylated azido-labeled N-acetylgalactosamine and then reacted, in the first click reaction, with...

Monoaryloxide-pyrrolide (MAP) olefin metathesis catalysts of molybdenum that contain a chiral bitetralin-based aryloxide ligand are efficient for ethenolysis of methyl oleate, cyclooctene, and cyclopentene. Ethenolysis of 5000 equiv of methyl oleate produced 1-decene (1D) and methyl-9-decenoate (M9D) with a selectivity of >99%, yields up to 95%, and a TON (turnover number) of 4750 in 15 h. Tung...

Post-synthesis DNA modification is a very useful method for DNA functionalization. This is achieved by using a modified NTP, which has a handle for further modifications, replacing the corresponding natural NTP in polymerase-catalyzed DNA synthesis. Subsequently, the handle can be used for further functionalization after PCR, preferably through a very fast reaction. Herein we describe polymeras...

Framework Ti-substituted, 3-D hexagonal mesoporous, Ti-SBA-12, obtained for the first time by direct hydrothermal synthesis, oxidises bulky molecules such as cyclohexene and cyclooctene to the epoxides with >96% selectivity at high conversion levels (>60%).

Here, we report a method to specifically bind liposomal radiopharmaceuticals to a CoCrMo alloy, which can be used in arterial stents, via an irreversible inverse electron-demand Diels-Alder reaction. Inspired by recent accomplishments in pre-targeted imaging using tetrazine-trans-cyclooctene click chemistry, we synthesized 89Zr-labeled trans-cyclooctene-functionalized liposomal nanoparticles, w...

In a previous study, the authors showed that iron(III) [tetrakis(pentafluorophenyl)]porphyrin chloride [(F20TPP)FeCl] is catalytically inactive for cyclooctene epoxidation by hydrogen peroxide in acetonitrile but is catalytically active if the solvent contains methanol. It was suggested that the precursor to the active species is (F20TPP)Fe(OCH3) in methanol-containing solvents. The present stu...

Treatment of [AuCl(PBu(t)(3))] with AgSbF(6) in CH(2)Cl(2) at room temperature in the presence of the alkenes norbornene, norbornadiene, trans-cyclooctene, and also interestingly, isobutylene, leads to the formation of stable crystalline complexes [Au(PBu(t)(3))(alkene)][SbF(6)], characterised by NMR spectroscopy and X-ray crystallography.

Arenetricarbonyl metal complexes ([-phM(CO)3-] and [-biphM(CO)3-]; ph = phenylene, biph = biphenylene, M = Mo, Cr) constructed within Zr-based MOFs act as highly active and selective catalysts for epoxidation of cyclooctene. Catalytic activities of these complexes are enhanced with increasing the pore sizes of Zr-based MOFs.