minutes before training (5), we sought to determine whether such injections of amphetamine also antagonize the effects of cycloheximide on activity. Mice were first injected with cycloheximide; 3 hours and 45 minutes later, they were injected subcutaneously with amphetamine (1 mg/kg) or saline. This interval between drug injections is the same one employed in memory studies, where amphetamine, ...

Prior studies have indicated that effects of cholera enterotoxin (CT) on the small intestine are delayed in onset and involve an interaction with adenyl cyclase in the mucosa. It has also been shown that the administration of cycloheximide to rabbits in doses which inhibit crypt cell mitoses (20 mg/kg), diminishes CT-induced fluid production in jejunal loops. These latter studies have been inte...

Pseudomonas savastanoi pv. causes olive knot disease that afflicts trees globally. A sensitive and reproducible in vitro pathogenicity bioassay using detached leaf segments was developed after isolation of Psav on KB medium amended with vancomycin, cephalexin cycloheximide. Symptoms were clear under 20X magnification 10 days. This will facilitate rapid screening germplasm collection for resista...

Trypsin-dissociated cells from the muscle tissue of 9-day-old chick embryos were employed to investigate the effects of cycloheximide and a puromycin-cycloheximide mixture on cell aggregation, protein synthesis and respiratory metabolism. Cycloheximide when introduced at a concentration of 10 /Jg/ml into a suspension of cells in Eagle's MEM inhibited aggregation by 25 % at 24 h. At this time an...

Tetrahymena is able to adapt to the presence of sublethal concentrations of many drugs which inhibit a wide variety of cellular functions. In spite of the generality of this phenomenon in Tetrahymena, the mechanism of adaptation at the cellular and molecular levels is unknown. This study deals mainly with adaptation to the protein synthesis inhibitors, cycloheximide and emetine. The physiologic...

reconsolidation memory is defined as a process in which the retrieval of a previously consolidated memory returns to a labile state which is then subject to stabilization. previous studies have shown that mineralocorticoid receptors (mrs) modulate distinct phases of learning and memory, which display a high concentration and distinct distribution in the hippocampus. moreover, we found no studie...

Although cycloheximide is extremely inhibitory to protein synthesis in vivo in higher plants, the reported insensitivity of some plant ribosomes suggests that it may not invariably act at the ribosomal level. This suggestion is reinforced by results obtained with red beet storage tissue disks, the respiration of which is stimulated by cycloheximide at 1 microgram per milliliter. Inorganic ion u...