background: cyclo-oxygenase-2 (cox-2) is an early response gene that is induced by growth factors, oncogenes and carcinogens and its expression is increased in various tumors. increased expression of cox-2 plays a signifi cant role in the development and growth of tumors by interfering in biological processes such as cell division, cellular immunity, cell adhesion, apoptosis, and angiogenesis. ...

Resident mouse peritoneal macrophages rapidly metabolize free arachidonic acid (20:4) in the absence of a discernible trigger. After a 20-min incubation in serumless medium, one-third of the fatty acid was found esterified in cell phospholipid and two-thirds was metabolized to oxygenated products which were recovered in the culture medium. The 20:4 oxygenated metabolites were identified by reve...

A cyclo-oxygenase metabolite of arachidonic acid, prostaglandin F, appears to be closely involved in the stimulation of protein synthesis by insulin in skeletal muscle [l] and in L6 myoblasts [2]. At present, however, it is not clear if the cyclo-oxygenase pathway is the only route leading to increased protein synthesis in skeletal muscle. In 3T3 fibroblasts, exogenous diacylglycerol has been s...

OBJECTIVE The comparative risk of myocardial infarction (MI) with cyclo-oxygenase-2-specific drugs and traditional non-steroidal anti-inflammatory drugs (NSAIDs) was determined. METHODS The results of studies of a suitable size in colonic adenoma and arthritis-that had been published in English and from which crude data about MIs could be extracted-were evaluated. Medline, Embase and Cinahl (...

Recent data have suggested that regular consumption of nonsteroid anti-inflammatory drugs (NSAIDs), particularly selective inhibitors of cyclo-oxygenase-2 (COX-2), is associated with an increased risk of thrombotic events. It has been suggested that this is due to NSAIDs reducing the release from the endothelium of the antithrombotic mediator prostaglandin I2 as a result of inhibition of endoth...