The preparation of the title compound, C26H25N, was achieved by the condensation of an ethano-lic mixture of benzaldehyde, cyclo-hexa-none and ammonium acetate in a 2:1:1 molar ratio. There are two crystallographically independent mol-ecules in the asymmetric unit. The two cyclo-hexyl rings adopt an anti-envelope conformation with the benzyl moiety adopting a cis conformation with respect to th...

Twofold Perkin condensation of 2,5-dibromophenylene-1,4-diacetic acid with arylglyoxylic acids followed by cyclo-dehydrobromination leads to dipyreno- and diperyleno-anthracene tetraesters and diimides. The imides show surprisingly large absorption shifts versus the esters, illustrating that electron-withdrawing substituents at the anthracene unit efficiently impart long wavelength absorption i...

The title compound, C(24)H(26)O(3), was prepared by the condensation reaction of 4-ethoxy-benzaldehyde with cyclo-hexa-none. The mol-ecule has crystallographic mirror symmetry and exhibits a butterfly-shaped geometry, with a dihedral angle of 5.46 (1)° between the two benzene rings. Weak inter-molecular C-H⋯π inter-actions help stabilize the crystal structure.

The title compound, C(15)H(17)FO, was prepared directly from the aldol condensation of cyclo-octa-none with 4-fluoro-benz-aldehyde, catalysed by Pd(Ni,Ce) in the presence of trimethyl-silyl chloride. The eight-membered ring adopts a boat-chair conformation.

BACKGROUND An increasing number of cyclic dipeptides (CDPs), particularly those containing proline, have been shown to exhibit important biological activity. MATERIALS AND METHODS We investigated the potential of seven proline-based CDPs to inhibit cancer cell growth in HT-29, HeLa and MCF-7 cell lines. We also tested whether any of the CDPs were able to induce apoptosis in HT-29 cells. RES...

A highly simple, rapid, sensitive and selective method is developed for spectrophotometric determination of gabapentin in pure form as well as in pharmaceutical formulations. The method is based on the formation of a yellow Schiff base derived from the condensation of gabapentin drug (1-amino methyl) cyclo hexane acetic acid and 2,5-dihydroxybenzaldehyde (DHBA) exhibiting a maximum absorbance a...

The title compound, C(18)H(21)NO(3), was obtained via a double Mannich condensation reaction of 6-methyl-tetra-hydro-isobenzofuran-1,7(3H,7aH)-dione with formaldehyde and benzyl-amine. The mol-ecule contains three fused rings of which the cyclo-hexa-none and piperidine rings adopt chair conformations and the furan-one ring assumes an envelope conformation. An inter-molecular C-H⋯π inter-action ...

The research work reports facile, eco-friendly microwaveassisted solvent free synthesis of coupled heterocyclic system 2-(1Hindol-3-yl)-4-substitued-2, 3-dihydrobenzo [1, 5] thiazepine derivatives obtained by cyclo condensation of 1-substituted-3(1Hindolyl)-2-propen-1-ones with 2-amino thiophenol in presence of eco-friendly catalyst zirconium(IV) oxy chloride, in solvent-free conditions. The re...

bis(indolyl)methanes are important group of bioactive metabolites of terrestrial and marine regions. they were synthesized by different methods. herein, a clean, one-pot synthesis of bis(indolyl)methane derivatives by cyclo-condensation reaction of indole and various aldehydes using sulfonic acid functionalized silica (sio2-pr-so3h) in aqueous media is reported. the advantages of this new metho...

The title compound, C(20)H(20)Br(2)ClN(3)O(3), was synthesized by the condensation reaction of 2-chloro-5-nitro-benzaldehyde with 4-(2-amino-3,5-dibromo-benzyl-amino)cyclo-hexa-nol in a methanol solution. There are two independent mol-ecules in the asymmetric unit and in one mol-ecule the atoms of the cyclo-hexane ring are disordered over two sets of sites with refined occupancies of 0.657 (12)...