cyclic voltammogram and differential pulse polarograph of octaethyl porphyrin iron(iii) chloride in dichloromethane was investigated in the presence of pyridine, imidazole and collidine. values of e1/2 for feiii/feii redox reaction were monitored as a function of axial group concentration, and on the basis of these data, an overall oxidation-reduction and ligand addition scheme was formulated. ...

Correction for ‘“Give me five” – an amino imidazoline-2-imine ligand stabilises the first neutral five-membered cyclic triel(i) carbenoides’ by Lars Denker et al., Chem. Commun., 2021, 57, 2816–2819, DOI: 10.1039/D1CC00010A.

One major goal of ion channel research is to delineate the molecular events from the detection of the stimuli to the movement of channel gates. For ligand-gated channels, it is challenging to separate ligand binding from channel gating. Here we studied the cyclic adenosine monophosphate (cAMP)-dependent gating in hyperpolarization-activated cAMP-regulated (HCN) channel by simultaneously recordi...

Protein relaxation, ligand binding, and ligand migration into a hydrophobic cavity in myoglobin are unified by a bounded diffusion model which produces an accurate fit to complex ligand rebinding data over eight decades in time and a 160 K temperature range, in qualitative agreement with time-resolved x-ray crystallography. Protein relaxation operates in a cyclic manner to move the ligand away ...

BACKGROUND Combinatorial methods for the production of molecular libraries are an important source of ligand diversity for chemical biology. Synthetic methods focus on the production of small molecules that must traverse the cell membrane to elicit a response. Genetic methods enable intracellular ligand production, but products must typically be large molecules in order to withstand cellular ca...

Abstract Novel l ‐tartaric acid based stereodynamic biphenylbisphosphinite ligands with anilino linkers were prepared as cyclic diamide compounds. The influence of the constitutional substitution pattern amino group at aniline moiety on diastereoselective formation ligand was investigated. While meta ‐anilino bridged showed a highly dynamic behavior and no discrimination between ( R ax ) S conf...

an octahedral cobalt(iii) complex, trans-[(me2bpb)co(bzlan)2]clo4 (1), with h2me2bpb = n,n’-(4,5-dimethyl-1,2-phenylene)dipicolinamide and bzlan = benzylamine, has been synthesized and characterized by elemental analyses, ir, uv-vis, and 1h nmr spectroscopy. the structure of this complex has been determined by x-ray crystallography. the me2bpb2– is a di-anionic tetradentate ligand furnishing a ...

The adhesion of mammalian cells is mediated by the binding of cell-surface integrin receptors to peptide ligands from the extracellular matrix and the clustering of these receptors into focal adhesion complexes. This paper examines the effect of one mechanistic variable, ligand affinity, on the assembly of focal adhesions (FAs) in order to gain mechanistic insight into this process. This study ...

Herein, we report a ruthenium‐catalyzed ketone directed ortho‐arylation wherein the addition of bidentate NC‐type ligand, most effectively 2‐(o‐tolyl) pyridine, significantly enhances C‐H arylation reaction. Various aryl‐alkyl ketones, including cyclic, aliphatic, and heterocyclic ones, are competent substrates, arylboronic acid esters were used as aryl sources. However, substitution with OMe C...