Mycobacterium tuberculosis (Mtb) secretes excess of a second messenger molecule, 3',5'-cyclic AMP (cAMP), which plays a critical role in the survival of Mtb in host macrophages. Although Mtb produces cAMP in abundance, its exact role in the physiology of mycobacteria is elusive. In this study we have analyzed the expression of 16 adenylate cyclases (ACs) and kinetics of intracellular cAMP level...

the recent literatures indicate that central nervous system (cns) is highly vulnerable to systemic hyperthermia induced by whole body heating on conscious animals. in the present study, cerebral electrical activity or eeg (electroencephalogram) following exposure to high environmental heat has been studied in moving rats. rats were divided into three group (i) acute heat stress-subjected to a s...

Recently, the thermosensing pathway in sponges (Porifera) was elucidated. The thermosensor triggering this cascade is a heat-activated cation channel, with the phytohormone abscisic acid (ABA), cyclic ADP-ribose (cADPR) and calcium acting as intracellular messengers, similarly to the drought-stress signaling cascade in higher plants. Here, we investigated the functional effects downstream of th...

This work studies the effects of water deficit and heat, as well as the involvement of chlororespiration and the ferredoxin-mediated cyclic pathway, on the tolerance of photosynthesis to high light intensity in Hibiscus rosa-sinensis plants. Drought and heat resulted in the down-regulation of photosynthetic linear electron transport in the leaves, although only a slight decrease in variable flu...

heat stress is well recognized among the hazardous physical agents that might be present during work. this study aims to compare wbgt index at acclimated and unacclimated people to permissible threshold limit value and study the differences between physiological parameters at them. twenty one healthy men were participated in the study. all of the subjects were monitored in two different weather...

with the expanding demand on application of magnesium alloys in automotive and aerospace industries, robust methods in fatigue characterization of commercially available magnesium alloys with high specific strength is anticipated. in this paper, rotating bending load controlled tests has been studied on specimens machined from an extrusion piece of az31b. due to asymmetric and anisotropic behav...

terminal heat stress is the most widespread heat stress in the world. in order to evaluate the effect of heat stress on yield, yield component, and mopho-phenological traits of barley, 10 barley genotypes including the 2-row genotypes: mahour, khoram, nimrooz, abidar and 6-row genotypes: yousef, rihan 03, izeh, zahak, nosrat, jonoub were tested under normal (optimum sowing date) and heat stress...

p38, a subfamily of the mitogen-activated protein kinases (MAPKs), is a crucial signal transducer between a variety of extracellular stimuli and gene expression in mammalian cells. This kinase is activated in cultured cells stimulated by heat shock, osmotic stress, and proinflammatory cytokines, but a similar activation of p38 MAPKs in vascular smooth muscle cells (SMCs) stimulated by mechanica...