Diverse treatments, which have been shown by Slayman, C. L. (1977) in Water Relations in Membrane Transport in Plants and Animals (Jungreis, A., Hodges, T. K., Kleinzeller, A., and Schultz, S. G., eds) pp. 69-86, Academic Press, New York, to depolarize the plasma membrane of Neurospora, increase levels of adenosine 3':5'-monophosphate (cyclic AMP) in the organism. The treatments include those p...

Two protein phosphokinases (EC 2.7.1.37) were found to be present in rabbit reticulocytes. The two enzymes were separated by DEAE-cellulose chromatography and called kinases I and II. Adenosien 3':5'-cyclic monophosphate stimulated the activity of both enzymes. However, the degree of stimulation was different and depended on the protein acceptor used. In the presence of adenosine 3':5'-cyclic m...

The adenylate cyclase toxin (ACT) of Bordetella pertussis intoxicates target cells by generating supraphysiologic levels of intracellular cyclic AMP (cAMP). Since ACT kills macrophages rapidly and potently, we asked whether ACT would also kill neutrophils. In fact, ACT prolongs the neutrophil life span by inhibiting constitutive apoptosis and preventing apoptosis induced by exposure to live B. ...

Cavities formed using cyclic tetrapeptides (CTPs) or heat-induced conformers act as templates for cyclization; the cavities bind to linear tetrapeptides and enforce turn conformations to enhance cyclization to constrained CTPs.

We shall determine the uniquely existing extension of the alternating group of degree 6 (being normal in the group) by a cyclic group of order 4, which can act on a complex K3 surface.

The purpose of this study was to examine the mechanisms underlying adrenergic-cholinergic antagonism in ventricular myocardium. Myocardial contractility, cyclic adenosine monophosphate (AMP) levels, and cyclic guanosine monophosphate (GMP) levels were measure in isolated guinea pig ventricles after treatment with various inotropic agents given alone and simultaneously with acetylcholine. Acetyl...

Squamous metaplasia ¡sa common abnormality of cellular development and differentiation in the epithelia of many organs, including the prostate gland in humans. Agents known to elevate the level of intracellular cyclic adenine nucleotide have been found to direct various kinds of epithelial cells onto a pathway of epidermoid (squamous) development and a differ entiation marked by keratin produc...

Squamous metaplasia ¡sa common abnormality of cellular development and differentiation in the epithelia of many organs, including the prostate gland in humans. Agents known to elevate the level of intracellular cyclic adenine nucleotide have been found to direct various kinds of epithelial cells onto a pathway of epidermoid (squamous) development and a differ entiation marked by keratin produc...