We develop the core of a method for solving the data archive and curation problem that confronts the custodians of restricted-access research data and the scientific users of such data. Our solution recognizes the dual protections afforded by physical security and access limitation protocols. It is based on extensible tools and can be easily incorporated into existing instructional materials.

Organizations responding to requests to produce electronically stored information (ESI) for litigation today often conduct information retrieval with a limited amount of data that has first been culled by custodian mailboxes, date ranges, or other factors chosen semi-arbitrarily based on legal negotiations or other exogenous factors. The culling process does not necessarily take into account th...

BACKGROUND Balancing the rights and obligations of custodians and applicants in relation to access to biobanks is of utmost importance to guarantee trust and confidence. This study aimed to reveal which issues divide different stakeholders in an attempt to determine the rights and/or obligations held on human biological materials (HBM) and data. METHODS Twenty-eight informants in the Benelux ...

Germline mutations in BRCA1 and BRCA2 predispose to common human malignancies, most notably tumors of the breast and ovaries. The proteins encoded by these genes have been implicated in a plethora of biochemical interactions and biological functions, confounding attempts to coherently explain how their inactivation promotes carcinogenesis. Here, I argue that tumor suppression by BRCA1 and BRCA2...

, 1470 (2014); 343 Science Ashok R. Venkitaraman BRCA2 Cancer Suppression by the Chromosome Custodians, BRCA1 and This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or re...