An UPLC-UV-MS method was developed for the determination of curcuminoids and ar-turmerone from roots of Curcuma longa L., different species of Curcuma (C. zedoaria, C. phaecaulis, C. wenyujin and C. kwangsiensis) and dietary supplements that claimed to contain C. longa. The separation was achieved within 3.5 minutes using a C-18 column, a water/acetonitrile mobile phase, containing formic acid ...

SUMMARY Curcuminoids, components of the rhizome of turmeric, show several beneficial biological activities, including anticarcinogenic, antioxidant, anti-inflammatory, and antitumor activities. Despite their numerous pharmaceutically important properties, the low natural abundance of curcuminoids represents a major drawback for their use as therapeutic agents. Therefore, they represent attracti...

Curcuminoids are phenylpropanoids with high pharmaceutical potential. Herein, we report an engineered artificial pathway in Escherichia coli to produce natural curcuminoids through caffeic acid. Arabidopsis thaliana 4-coumaroyl-CoA ligase and Curcuma longa diketide-CoA synthase (DCS) and curcumin synthase (CURS1) were used to produce curcuminoids and 70 mg/L of curcumin was obtained from feruli...

BACKGROUND The oral bioavailability of curcuminoids is low, but can be enhanced by incorporation into micelles. The major curcuminoid curcumin has antitumor effects on glioblastoma cells in vitro and in vivo. We therefore aimed to determine intratumoral concentrations and the clinical tolerance of highly bioavailable micellar curcuminoids in glioblastoma patients. METHODS Thirteen glioblastom...

An HPLC method using fluorescence detection for the quantitation of curcuminoids, such as curcumin (C), demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC) in turmeric products is described. This method involves a simple ultrasonic extraction with methanol as a pretreatment of turmeric products. The separation of curcuminoids and 2,5-xylenol (internal standard) was achieved within 30 min o...

STAT-3 and STAT-1 signaling have opposite effects in oncogenesis with STAT-3 acting as an oncogene and STAT-1 exerting anti-oncogenic activities through interferon-γ and interferon-α. The cytokine IL-6 promotes oncogenesis by stimulation of NFκB and STAT-3 signaling. Curcuminoids have bi-functional effects by blocking NFκB anti-apoptotic signaling but also blocking anti-oncogenic STAT-1 signali...

In a search for plant extracts with potent antimicrobial activity, turmeric (Curcuma longa) was extracted to get volatile oil and total curcuminoids .Further total curcuminoids portion was isolated by column chromatography to get curcumin , bisdemethoxycurcumin and demethoxycurcumin. The isolated curcuminoids were identified and characterized by melting point, thin layer chromatography, infra r...

1,5-Bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadiene-3-one (2) was isolated from Curcuma domestica as a curcumin (1)-related compound, which we named C5-curcumin. Intrigued by the potent antitumor activity of C5-curcumin (2)-related 1,5-bisaryl-1,4-pentadiene-3-ones [bis(arylmethylidene)acetones, termed C5-curcuminoids], we previously conducted a structure-activity relationship study of C5-curcumi...

Curcuminoids refer to three main chemical substances, namely curcumin, demethoxycurcumin, and bis-demethoxycurcumin. These are used as natural coloring agents in some food products and have been reported to exhibit several biological activities in animal and human clinical studies. Due to its beneficial effects to human health, several analytical methods have been continuously proposed and deve...

The current study aimed mainly to configurate any changes in selected neurotransmitters pattern, some inflammatory markers , oxidative stress in the brain of alloxan diabetic rats and to illustrate any relation between neurotransmitters activity and the inflammation degree . Effect of Fish oil and curcuminoids either individually or in association form were tested as neuroprotective agents. Mat...