perform regioand stereo-selective reactions on organic compounds. The different possible microbial reactions include oxidation, reduction, and degradative reactions. Many of these reactions allow the production of new compounds that would be extremely difficult to synthesize chemically. For instance hydroxylation at inactivated methylene is a very common microbial reaction. The results obtained...

Milbemycins are a family of sixteen-membered macrolides produced by Streptomyces hygroscopicus subsp. aureolacrimosus. They exhibit broad-spectrum insecticidal and acaricidal activity. * ~ 3) In the course of our studies on the microbial conversion of milbemycins, we obtained 13/?hydroxymilbemycins A4, A3, D, 13/Miydroxy-LLF28249a, 28-hydroxymilbemycin D, and 28-hydroxy-LL-F28249a by using Cunn...

Metabolic stability, mutagenicity, antimutagenicity, and the ability to scavenge free radicals of four novel 8-methoxy-purine-2,6-dione derivatives (compounds 1-4) demonstrating analgesic and anti-inflammatory properties were determined. Metabolic stability was evaluated in Cunninghamella and microsomal models, mutagenic and antimutagenic properties were assessed using the Ames and the Vibrio h...

Disseminated mucormycosis occurred in a 19 year old female following orthotopic liver transplantation for fulminant Wilson's disease. The causative organism Cunninghamella bertholletiae has previously been described in ten clinical cases, but never before in this setting.

The first fatal Cunninghamella bertholletiae infection in a clinically immunocompetent host is reported. This case differs from previously reported cases by the lack of extensive vascular invasion and thrombosis.

Fungi is a well-known model used to study drug metabolism and its production in in vitro condition. We aim to screen the most efficient strain of Cunninghamella sp. among C. elegans, C. echinulata and C. blakesleeana for bromhexine metabolites production. We characterized the metabolites produced using various analytical tools and compared them with mammalian metabolites in Rat liver microsomes...

The root-galling index of tomatoes inoculated with Meloidogyne javanica was decreased 70% when collagen was used as a soil amendment (0.1% w/w) and 90% when the amendment was supplemented with the collagenolytic fungus Cunninghamella elegans. The root-galling index was reduced 80% when the fungus was homogenized in collagen culture medium and added to soil without collagen supplement. Culture f...

The fatty acid pattern in hydrocarbon-utilizing filamentous fungi was determined after growth on acetate, propionate, n-alkanes (C(13) to C(15)), and alk-1-enes (C(14) to C(18)). The fatty acid profile of Cunninghamella elegans and Penicillium zonatum after growth on acetate shows a predominance of even-carbon fatty acids (C(16), C(18:1), C(18:2)), whereas cells grown on propionate showed signi...