BACKGROUND Current data suggest that mortality after noncardiac surgery may be associated with persistent hypotension and the cumulative duration of low processed electroencephalogram-based bispectral index (BIS). This study assessed the relationships among cumulative duration of low BIS (BIS < 45), intermediate-term mortality, and anesthetic dose after cardiac surgery. METHODS The authors st...

BACKGROUND Postoperative mortality has been associated with cumulative anesthetic duration below an arbitrary processed electroencephalographic threshold (bispectral index [BIS] <45). This substudy of the B-Unaware Trial tested whether cumulative duration of BIS values lower than 45, cumulative anesthetic dose, comorbidities, or intraoperative events were independently associated with postopera...

background increases in aminotransferases (transaminitis) are potential major adverse reactions seen with long-term use of methotrexate (mtx). the aim of this study, therefore was to evaluate the incidence of mtx induced hepatotoxicity and its risk factors among rheumatoid arthritis (ra) patients. methods this retrospective study described 286 patients with ra who received ≤ 7.5 mg mtx weekly...

torsion of many symmetric structures, which were designed based on the seismic codes, is due to their asymmetricity induced during inelastic behavior. although the structure was designed symmetrically assuming elastic based criteria, different factors such as material inconsistency in structure, construction details discrepancy and construction errors may result in asymmetric behavior in inelas...

The indentation process of pressing a Rockwell diamond indenter into inelastic material has been studied to provide a means for the analysis, simulation and prediction of Rockwell hardness tests. The geometrical characteristics of the spheroconical-shaped Rockwell indenter are discussed and fit to a general function in a self-similar way. The complicated moving boundary problem in Rockwell hard...

OBJECTIVE Metformin has been associated with a reduction in breast cancer risk and may improve survival after cancer through direct and indirect tumor-suppressing mechanisms. The purpose of this study was to evaluate the effect of metformin therapy on survival in women with breast cancer using methods that accounted for the duration of treatment with glucose-lowering therapies. RESEARCH DESIG...

Torsion of many symmetric structures, which were designed based on the seismic codes, is due to their asymmetricity induced during inelastic behavior. Although the structure was designed symmetrically assuming elastic based criteria, different factors such as material inconsistency in structure, construction details discrepancy and construction errors may result in asymmetric behavior in inelas...