نتایج جستجو برای: csf gene

تعداد نتایج: 1165569  

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2005
Yoshitaka Murata Akihide Tanimoto Ke-Yong Wang Masato Tsutsui Yasuyuki Sasaguri Filip De Corte Hiroshi Matsushita

OBJECTIVE To study the effect of granulocyte macrophage-colony-stimulating factor (GM-CSF) on histamine metabolism in arteriosclerosis, the expression of histidine decarboxylase (HDC; histamine-producing enzyme), histamine receptors 1 and 2 (HH1R and HH2R), and GM-CSF was investigated in human and mouse arteriosclerotic carotid arteries. Furthermore, the molecular mechanisms of GM-CSF-induced H...

Journal: :Cancer research 1997
J W Simons E M Jaffee C E Weber H I Levitsky W G Nelson M A Carducci A J Lazenby L K Cohen C C Finn S M Clift K M Hauda L A Beck K M Leiferman A H Owens S Piantadosi G Dranoff R C Mulligan D M Pardoll F F Marshall

Granulocyte-macrophage colony-stimulating factor (GM-CSF) gene-transduced, irradiated tumor vaccines induce potent, T-cell-mediated antitumor immune responses in preclinical models. We report the initial results of a Phase I trial evaluating this strategy for safety and the induction of immune responses in patients with metastatic renal cell carcinoma (RCC). Patients were treated in a randomize...

باقریه, فریبا,

Background and Objective: Extinction coefficient is the unique value to each protein and can evaluate the type and purity of recombinant protein produced in laboratories and factories producing recombinant proteins. In this study, a simple method for calculating the extinction coefficient of recombinant protein Granulocyte-Colony Stimulating Factor (G-CSF) is presented. Methods: G-CSF with...

Journal: :Journal of immunology 2012
Derek C Lacey Adrian Achuthan Andrew J Fleetwood Hang Dinh John Roiniotis Glen M Scholz Melody W Chang Sandra K Beckman Andrew D Cook John A Hamilton

GM-CSF and M-CSF (CSF-1) induce different phenotypic changes in macrophage lineage populations. The nature, extent, and generality of these differences were assessed by comparing the responses to these CSFs, either alone or in combination, in various human and murine macrophage lineage populations. The differences between the respective global gene expression profiles of macrophages, derived fr...

Journal: :The Journal of clinical investigation 1987
D C Young K Wagner J D Griffin

Expression of the granulocyte-macrophage colony-stimulating factor (GM-CSF) gene was studied by Northern blot analysis in normal human hematopoietic cells and a series of leukemias. GM-CSF messenger (m)RNA was detected in activated T cells, but not in normal bone marrow cells, monocytes, or nonactivated T cells. In contrast, leukemic cells from 11 of 22 cases of acute myeloblastic leukemia expr...

Journal: :iranian biomedical journal 0
مهریار حبیبی رودکنار mehryar habibi roudkenari سعید بوذری saeid bouzari مانا علومی mana oloomi انیس جعفری anis jafari نادر شاهرخی nader shahrokhi محمدعلی شکرگزار mohammad ali shokrgozar

fusion of two genes at dna level produces a single protein, known as a chimeric protein. immunotoxins are chimeric proteins composed of specific cell targeting and cell killing moieties. bacterial or plant toxins are commonly used as the killing moieties of the chimeric immunotoxins. in this investigation, the catalytic domain of shiga-like toxin (a1) was fused to human granulocyte macrophage c...

Journal: :iranian journal of microbiology 0
kamal ahmadi student research committee, faculty of medicine, kermanshah university of medical sciences, kermanshah, iran. alisha akya nosocomial infection research centre, school of medicine, kermanshah university of medical sciences, kermanshah, iran. bizhan numanpour student research committee, faculty of medicine, kermanshah university of medical sciences, kermanshah, iran and department of microbiology, school of medicine, kermanshah university of medical sciences, kermanshah, iran. afsaneh salimi department of biochemistry, school of medicine, kermanshah university of medical sciences, kermanshah, iran. asad veisi-raigani department of biochemistry, school of medicine, kermanshah university of medical sciences, kermanshah, iran.

background and objectives : streptococcus pneumoniae is the main causative agent of acute bacterial meningitis in the world. this study aimed to detect pneumoniae infection in cerebrospinal fluid (csf) samples of patients with suspected meningitis. materials and methods : in this study, 200 csf samples in patients with suspected meningitis and with negative bacterial cultures were tested. demog...

Journal: :Journal of immunology 2002
Fabio Re Svetlana L Belyanskaya Richiard J Riese Barbara Cipriani Falko R Fischer Francesca Granucci Paola Ricciardi-Castagnoli Celia Brosnan Lawrence J Stern Jack L Strominger Laura Santambrogio

Neonatal microglial cells respond to GM-CSF and M-CSF by acquiring different morphologies and phenotypes. To investigate the extent and consequences of this process, a global gene expression analysis was performed, with significant changes in transcript levels confirmed by biochemical analyses. Primary murine microglial cells underwent substantial expression reprogramming after treatment with G...

Journal: :Cancer research 1996
C A Armstrong R Botella T H Galloway N Murray J M Kramp I S Song J C Ansel

The use of immunomodulating gene therapy in the treatment of malignant disease is under intensive investigation. In this study, we examined the potential of melanoma-derived granulocyte-macrophage colony-stimulating factor (GM-CSF) to inhibit melanoma progression in a murine model. The HGH18 murine melanoma cell line was transfected with the murine GM-CSF gene in a SV40 expression vector that r...

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