PURPOSE To demonstrate the importance of collaboration between ophthalmologists and internists. DESIGN Cryoglobulinemia is a systemic vascularite. Ophthalmologic complications are rare and not well known. Purtscher-like retinopathy may occur in this context. CASE REPORT We report the case of a patient who presented a severe visual loss in the course of a hepatitis C. The ophthalmic examinat...

PURPOSE To report a case of peripheral ulcerative keratitis and necrotizing scleritis precipitated by trauma in a patient with mixed cryoglobulinemia due to hepatitis C viral infection. METHODS Case report and literature review. RESULTS A 62-year-old man with a history of mixed cryoglobulinemia developed an episode of necrotizing scleritis and peripheral ulcerative keratitis one month after...

To report the efficacy of rituximab plus belimumab in patients with refractory cryoglobulinemia vasculitis (CV). Belimumab was administered intravenously at a dose 10 mg/kg on days 0, 14, 28 and then every month association 4 CV. Demographic, clinical laboratory characteristics, treatment modalities outcomes were recorded. All had type II IgM Kappa cryoglobulinemia, which associated primary Sjö...

Cryoglobulinemia is a rare disease characterized by the production of monoclonal or polyclonal immunoglobulins that precipitate in cold temperature. While this phenomenon can be observed in a large number of disorders, it has been associated with hepatitis C virus infection in more than 90% of cases. The remaining 10%, called essential cryoglobulinemia, has been characterized by a more severe c...

Cryoglobulinemia is a rare disease characterized by the production of monoclonal or polyclonal immunoglobulins that precipitate in cold temperature. While this phenomenon can be observed in a large number of disorders, it has been associated with hepatitis C virus infection in more than 90% of cases. The remaining 10%, called essential cryoglobulinemia, has been characterized by a more severe c...

CONTEXT On the strength of epidemiological data,biological studies, and clinical findings, hepatitis C virus appears to be involved in the pathogenesis of a proportion of patients with non-Hodgkin lymphoma and cryoglobulinemia. OBJECTIVES The aim of this paper is to review the published literature focused on the current knowledge concerning hepatitis C virus and its potential role in the prod...

IMPORTANCE Cryoglobulins are cold-precipitating immunoglobulins that occur secondary to lymphoproliferative disorders, chronic viral infections, and autoimmune disorders. The treatment of cryoglobulinemia should target the underlying disorder; however, such an approach may be difficult, and therapeutic options remain limited for type I cryoglobulinemia. OBSERVATIONS We report a case of recalc...

To evaluate the efficacy of direct-acting antivirals (DAA) in patients with hepatitis C virus (HCV) associated cryoglobulinemia and monoclonal gammapathy (MG).

Three patients with cryoglobulinemia have been treated with automated plasma exchange procedures in which the replacement fluid was autologous plasma, obtained at a previous plasmapheresis and incubated in the cold to precipitate abnormal protein. All three responded with a reduction in cryoglobulin level and an improvement in clinical manifestations of cryoglobulinemia. The cost of treatment w...