Sediaan Orally Disintegrating Tablet (ODT) merupakan sistem penghantaran obat dengan disintegrasi yang cepat dalam waktu kurang dari 60 detik. ODT umumnya menggunakan bahan penghancur dapat mempercepat hancurnya tablet rongga mulut tanpa melalui proses pembentukan gel, antara lain crospovidone. Penelitian ini bertujuan mengetahui pengaruh penambahan crospovidone pembuatan loratadin metode granu...

Orally disintegrating tablets of Furosemide were prepared, evaluated and the comparison action different concentrations disintegrants on disintegration dissolution studied. Direct compression method was used to prepare orally containing 20 mg Furosemide. The formulation conducted using crospovidone, croscarmellose sodium starch glycolate as superdisintegrants their interactions with also FTIR. ...

The main objective of present research work is to formulate the Clopidogrel Fast Dissolving tablets. Clopidogrel, an antiplatelet drug, belongs to BCS Class-II and used to control Heart attack, Hypertension by inhibiting Platelet activation and aggregation .The Fast Dissolving tablets of Clopidogrel were prepared employing different concentrations of Crospovidone and Croscarmellose sodium in di...

Objective: The rationale of the current work is to design, develop and optimize mouth dissolving tablet ambrisentan treat hypertension. Methods: Sodium starch glycolate crospovidone were used as super disintegrants in direct compression method create nine mouth-dissolving formulations. Wetting time, drug content, vitro disintegration dispersion dissolution time all assessed for produced Results...

Objective: The present study was aimed to prepare and evaluate Donepezil HCl Orodispersible tablets (DO-ODTs) using natural synthetic superdisintegrants increase patient compliance. Methods: Direct compression adapted crospovidone, croscarmellose sodium as mucilage isolated from fruits of Abelmoschus esculentus at different concentrations along with microcrystalline cellulose aerosil. powder mi...

Oral administration of dosage form is the most recommended mode administration, because its self-medication, accurate dose drug, and ease administration. However, trouble swallowing in geriatric patients one major negative this route, which can mentally disrupt patients. The goal study was to use direct compression method make orodispersible tablets sulindac utilizing various doses super disint...

Aim. The choice of the qualitative and quantitative composition excipients to provide required mechanical strength disintegration time when developing a pharmaceutical in form orally disintegrating tablets (ODT) based on paracetamol N-acetyl-D-glucosamine. Materials methods. study object was pharmaceutically accepted used development solid dosage forms. To conduct statistical analysis experimen...

Introduction: Oro-dispersible tablets are rapidly dissolved in saliva without the need for water and beneficial renal impaired, bedridden psychiatric patients. Objective: The study aimed to formulate oro-dispersible of indomethacin with reduced adverse effects, better patient compliance, faster action, convenience Methods: were prepared using three different super disintegrants; crospovidone, c...

carbamazepine belongs to the class ii biopharmaceutical classification system (bcs) which is characterized by a high per-oral dose, a low aqueous solubility and a high membrane permeability. the bioavailability of such a drug is limited by the dissolution rate. in order to increase the drug dissolution, its solid dispersions were prepared by the cogrinding technique using an insoluble but highl...

Pravastatin sodium is available for oral administration as 10 mg, 20 mg, 40 mg, and 80 mg tablets. Inactive ingredients include: colloidal silicon dioxide, crospovidone, hydroxypropyl methylcellulose, magnesium stearate, mannitol, meglumine, microcrystalline cellulose and starch. The 10 mg, 20 mg and 80 mg tablets also contain D&C Yellow No 10 Aluminium Lake and the 40 mg tablet also contains D...