New era is an era of novel drug delivery systems. Pediatric, Geriatric and bed ridden patients have difficulties in swallowing tablets. The purpose of the present study was to develop and characterize mouth dissolving tablets of Levocetrizine Hydrochloride by using direct compression technique. Formulations were designed by factorial design technique. Sodium starch glycolate, Crospovidone and C...

In the present research work mouth dissolving tablets of domperidone were developed with superdisintegrants like crospovidone, croscarmellose sodium and sodium starch glycollate in various concentrations like 3%, 4% and 6% w/w by direct compression method. All formulations were evaluated for physical characteristics of compressed tablets such as weight variation, hardness, friability, content u...

Ezetimibe is a white, crystalline powder that is freely to very soluble in ethanol, methanol, and acetone and practically insoluble in water. Ezetimibe has a melting point of about 163°C and is stable at ambient temperature. ZETIA is available as a tablet for oral administration containing 10 mg of ezetimibe and the following inactive ingredients: croscarmellose sodium NF, lactose monohydrate N...

Amaç: Farklı üç süper dağıtıcının, ki bunlar; kroskarmeloz sodyum, sodyum nişasta glikolat ve Indion 414, doğrudan basım ile hazırlanan salbutamol sülfat oral dağılan tabletlerinde (ODT) hızlı dağıtma etkisi için ayrı ayrı veya ikili kombinasyonlarında çalışıldı. Gereç ve Yöntemler: ODT’ler farklı üç süper dağıtıcı kombinasyonunda; A, B ve C, hazırlandı. Herbir kombinasyonda süperdağıtıcıların ...

In the present study, novel co-processed superdisintegrants were developed by solvent evaporation method using crospovidone and croscarmellose sodium in the different ratios (1:1, 1:2 & 1:3) for use in the fast dissolving tablet formulations. The developed excipients were evaluated for angle of repose, Carr’s index and Hausner’s ratio in comparison with physical mixture of superdisintegrants. T...

In this study, mouth-disintegrating tablets of atenolol and atorvastatin combination were formulated using superdisintegrants to impart fast disintegration. Fifteen formulations were prepared based on different concentrations of two superdisintegrants, croscarmellose sodium and Kyron-T134. Three different techniques such as direct compression, effervescent and sublimation were used to study the...

Abstract: Introduction: The present study was carried out to formulate and evaluate orodispersible tablets of Apremilast with a purpose providing better patient compliance geriatric, pediatric, impaired, travelling non-cooperative patients suffering from psoriasis. Such are in need fast easy swallowing drug delivery system. Materials Methods: Apremilast-β-cyclodextrin inclusion complex prepared...

Rivaroxaban (RN) is a recently developed potent oral anticoagulant. The aim of the present study envisages compatibility studies rivaroxaban with crospovidone, sodium startch glycolate, magnesium stearate, talc, microcrystalline cellulose, aerosil, HPMC K100 M, croscarmellose using Differential scanning calorimeter and FTIR spectrophotometer. DSC thermograms, physical mixture individual pharmac...

Orodispersible drug formulations are a current trend in the pharmaceutical industry, mostly intended for pediatric and geriatric patients. Oral lyophilizates solid forms, either to be placed mouth or dispersed (or dissolved) water before administration. The correct excipient composition is prerequisite provide with appropriate visual appearance disintegration time. Typically, they composed of b...