of terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted noncommercial use, distribution, and reproduction in any medium provided article is properly cited. a Department of Pathology and Laboratory Medicine – David Geffen School of Medicine – University of California, Los Angeles/CA – USA. b Department of Pathology and Laboratory Medicine – Weill Cornell Me...

BACKGROUND Iron deficiency anaemia is a frequent complication of Crohn disease. Treatment with ferrous iron (Fe2-) compounds is often unsatisfactory and is associated with gastrointestinal side effects. Theoretically, oral iron supplementation may even be harmful, because iron may reinforce intestinal inflammation by catalysing production of reactive oxygen species. We investigated the effect o...

From the Departments of *General Surgery, †General Pathology and ‡General Internal Medicine, Vernon Jubilee Hospital, Vernon, BC T he association of Crohn disease and adenocarcinoma of the small intestine and colon has been well established. However, malignant carcinoid of the small intestine associated with Crohn disease is rare. We describe the case of a patient with an incidental malignant c...

Perianal disease is a well-recognized complication of Crohn disease and is often present when diagnosis is made (1,2). The reported incidence of perianal Crohn disease in the pediatric population varies between 13% and 62% (3–6). Anorectal stricture is a less common manifestation, and rarely are symptoms noted unless complicated by perianal sepsis or fistulae (7,8). Genital involvement is rare ...

OBJECTIVES Crohn disease is characterized by chronic intestinal inflammation in the absence of a recognized etiology. Nutritional therapy in the form of exclusive enteral nutrition (EEN) has an established role within pediatric Crohn disease. Following exclusive enteral nutrition's success, many dietary therapies focusing on the elimination of specific complex carbohydrates have been anecdotall...

BACKGROUND Arg702Trp, Gly908Arg, and Leu1007fsinsC variants of the NOD2 gene (nucleotide-binding oligomerization domain containing 2; alias, CARD15) influence the risk of Crohn disease. METHODS We conducted a systematic review to examine whether Arg702Trp, Gly908Arg, and Leu1007fsinsC are equally important risk factors for Crohn disease. In addition, we used studies for which combined informa...

Crohn disease is a chronic inflammatory condition that primarily affects the gastrointestinal tract. Typical manifestations include fever, weight loss, fatigue, and abdominal pain, and abdominal abscesses and fistulae are frequent complications. Abdominal actinomycosis is a subacute or indolent disease associated with Actinomyces spp. Symptoms can be very similar to those of Crohn disease, and ...

OBJECTIVE a strong association has been observed between celiac disease, generally its silent clinical form, and autoimmune disorders. A potential correlation with inflammatory bowel disease has also been suggested. Anti-tissue transglutaminase antibodies have been detected in Crohn´s disease. We investigated the prevalence of celiac disease in patients with autoimmune diabetes and in Crohn´s d...

P ostsurgical recurrence of Crohn disease is a very frequent event, and none of the drugs used for the purpose has really shown a clear-cut efficacy. Infliximab, a monoclonal antibody anti–tumor necrosis factor (anti–TNF), is very effective in the treatment of active Crohn disease, but its benefit in preventing postoperative recurrence is still unknown. Yet, its impact, both medical and economi...

Crohn disease pathogenesis is the result of the complex interaction between environmental factors (i.e. micro-flora in the gut), immunologic and genetic predisposition (1, 2). The bacterial pathogenesis hypothesis in Crohn disease is based on experimental data and clinical observation. The first studies in rodent models, such as those in transgenic HLA-B27 rats and many others in mice, demonstr...