Purpose The purpose of this study was to determine how the architecture of the lamina cribrosa (LC) microstructure, including the shape and size of the lamina pores, influences the IOP-induced deformation of the neural tissues within the LC pores using computational modeling. Methods We built seven specimen-specific finite element models of LC microstructure with distinct nonlinear anisotropi...

Since 1938, nine cases of nasopharyngeal involvement by craniopharyngioma have been described in the medical literature (1–3). Six of these cases involved the sella turcica, and all but one (1) extensively involved the sphenoid sinus. We report a case of a nasopharyngeal craniopharyngioma sparing the sella turcica. The tumor is thought to have likely arisen from the pharyngeal hypophysis. Magne...

INTRODUCTION Intranasal meningoceles occur as a result of herniation of the meninges into the nasal cavity through a defect in the cribriform plate. These are commonly found in the pediatric population due to a congenital defect in the skull base. Intranasal meningoceles are very rare in adults, and tend to arise only when engendered by trauma. Here, we present the case of a patient with seemin...

We demonstrate an automated segmentation method for in-vivo 3D optical coherence tomography (OCT) imaging of the lamina cribrosa (LC). Manual segmentations of coronal slices of the LC were used as a gold standard in parameter selection and evaluation of the automated technique. The method was validated using two prototype OCT devices; each had a subject cohort including both healthy and glaucom...

Olfactory neuroblastoma (esthesioneuroblastoma) was first described by Berger and Luc in 1924. It is considered to be an uncommon malignancy of the nasal cavity. The tumor arises from the specialized sensory epithelial olfactory cells, normally situated at the upper part of the nasal cavity, including the superior nasal concha, the roof of the nose and the cribriform plate. The imaging modaliti...

A major pathway by which cerebrospinal fluid (CSF) is removed from the cranium is transport through the cribriform plate in association with the olfactory nerves. CSF is then absorbed into lymphatics located in the submucosa of the olfactory epithelium (olfactory turbinates). In an attempt to provide a quantitative measure of this transport, 125I-human serum albumin (HSA) was injected into the ...

OBJECTIVE To examine the methods of extracranial repair of traumatic defects in the cribriform plate and ethmoid roof resulting in persistent cerebrospinal fluid (CSF) rhinorrhea in pediatric patients. DESIGN Retrospective case series. SETTING A single-institution, tertiary care, pediatric hospital. PATIENTS Four children, ranging in age from 3 1/2 to 9 years, who sustained fractures in t...

THE optic disc is an intriguingly small and intricate structure. Some of the pathological processes known or assumed in other conditions can be of help to us in elucidating the changes occurring in papilloedema. By papilloedema in this study I mean the non-inflammatory type found typically in cases of raised intracranial pressure, but also occurring, as we shall see, in some other conditions. T...

The safety and efficacy of cell-based therapies for neurodegenerative diseases depends on the mode of cell administration. We hypothesized that intranasally administered cells could bypass the blood-brain barrier by migrating from the nasal mucosa through the cribriform plate along the olfactory neural pathway into the brain and cerebrospinal fluid (CSF). This would minimize or eliminate the di...

Objective Compare nasal endoscopy with 3 mm versus conventional 4 mm rigid 30° endoscopes for visualization, patient comfort, and examiner ease. Methods Ten adults with no previous sinus surgery underwent bilateral nasal endoscopy with both 4 mm and 3 mm endoscopes (resulting in 20 paired nasal endoscopies). Visualization, patient discomfort and examiner's difficulty were assessed with every ...