Lipid esters stored in cytoplasmic lipid droplets (CLDs) of hepatocytes are used to synthesize very low-density lipoproteins (VLDLs), into which apolipoprotein B (ApoB) is integrated cotranslationally. In the present study, by using Huh7 cells, derived from human hepatoma and competent for VLDL secretion, we found that ApoB is highly concentrated around CLDs to make “ApoB-crescents.” ApoB-cresc...

BACKGROUND The pathogenesis of crescentic glomerulonephritis (CGN) involves cellular migration and proliferation in the urinary space, frequently followed by fibrous organization. Extracellular matrix proteoglycans (PGs) may regulate these events via effects on cellular migration, interactions with growth factors, including transforming growth factor-beta (TGF-beta), and control of collagen fib...

The following is the description ol' plate XXII (figures 1 to 16) illustrating the article on Developing gametocytes and schizonts of Plasmodium falciparum ; A case showing all stages in the peripheral circulation', by B. M. Das Gupta and S. K. Ganguli, published in the October issue of the Gazette (p. 458) which was, by error, omitted. Figures 1 to 7 developing crescents, 6 and 7 showing two i...

The atomic force microscope images surfaces by sensing the forces between a sharp tip and a sample. If the tip-sample interaction is dominated by short-range forces due to the formation of covalent bonds, the image of an individual atom should reflect the angular symmetry of the interaction. Here, we report on a distinct substructure in the images of individual adatoms on silicon (111)-(7x7), t...

1. The only cytoplasmic inclusions visible in the living neurone are lipid globules and mitochondria. 2. In both Helix and Limnaea there are three kinds of lipid globules, as follows: (a) large globules, yellowish from their carotinoid content; (6) smaller globules, easily coloured by vital dyes; (c) small globules, not colourable by vital dyes. 3. The crescents and rings ('dictyosomes') seen i...

Kidney has three main histological compartments including glomerular, vascular and tubulointerstitial. First, an approach should be performed to localize in which department the main injury occurs and to recognize the severity and extent of the renal injury in each department. Then, the type of injury is to be assessed such as active versus chronic. Active lesions includes cellular proliferatio...

BACKGROUND There are few reports of glomerulonephritis (GN) with crescents and a rapidly progressive course that lead to a diagnosis of a previously unsuspected B-cell dyscrasia. CASE PRESENTATION We report a case of rapidly progressive GN: the patient showed no evidence of etiology at the time of biopsy and was diagnosed as IgA multiple myeloma (MM) during investigation based on a renal biop...

BACKGROUND IgA nephropathy (IgAN) may progress to renal failure for some patients without any clinical risk factors and it is not unusual to find severe pathologic damage in clinically mild IgAN. We therefore investigated whether urinary kidney injury molecule-1 (KIM-1) was related to pathologic involvement in clinically mild IgAN. METHODS Urinary KIM-1/creatinine of 51 IgAN patients with nor...