Depressive disorder will be the second highest disease burden worldwide, which will impair life quality, reduce productivity, and increase disability and mortality. LBP is the main active fraction purified from Lycium barbarum. The aim of this study was to evaluate the potential therapeutic effects of LBP on depressive mice induced by reserpine, as well as the relevant mechanisms. The antidepre...

Crenosoma vulpis is a metastrongylid parasite of worldwide distribution, which inhabits the trachea, bronchi and bronchioles of many Canidae. The pathogenesis of crenosomiosis in the dog has been described by Stockdale and Hulland (1970). They note that transmission of infection is effected by ingestion of land snails or slugs harbouring the infective third-stage larvae, and that larval migrati...

Depressive disorder will be the second highest disease burden worldwide, which will impair life quality, reduce productivity, and increase disability and mortality. LBP is the main active fraction purified from Lycium barbarum. The aim of this study was to evaluate the potential therapeutic effects of LBP on depressive mice induced by reserpine, as well as the relevant mechanisms. The antidepre...

The properties of microglia largely differ depending on aging as well brain regions. However, there are few studies that investigated the functional importance such heterogeneous at molecular level. Voltage-gated proton channel, Hv1/VSOP, could be one candidates which confers heterogeneity among since it regulates oxidative stress in age-dependent manner. In this study, we found Hv1/VSOP shows ...

The G9a/G9a-like protein (GLP) histone lysine dimethyltransferase complex and downstream H3 9 dimethylation (H3K9me2) repressive mark have recently emerged as key transcriptional regulators of gene expression programs necessary for long-term memory (LTM) formation in the dorsal hippocampus. However, role hippocampal G9a/GLP mediating consolidation spatial LTM remains largely unknown. Using a wa...

The entopeduncular nucleus is one of the basal ganglia's output nuclei, thereby controlling ganglia information processing. Entopeduncular neurons integrate GABAergic inputs from Striatum and globus pallidus, together with glutamatergic subthalamic nucleus. We show that endocannabinoids dopamine interact to modulate long-term plasticity all these primary afferents Our results suggest interplay ...

Associating spatial locations with rewards is fundamental to survival in natural environments and requires the integrity of the hippocampus and ventral striatum. In joint multineuron recordings from these areas, hippocampal-striatal ensembles reactivated together during sleep. This process was especially strong in pairs in which the hippocampal cell processed spatial information and ventral str...