BACKGROUND AND PURPOSE The Cincinnati Prehospital Stroke Scale (CPSS) is recommended for emergency medical services use in identifying patients with stroke. Data evaluating its performance in the field are limited. We assessed the impact of training and use of the CPSS on the accuracy of paramedics' stroke patient identification and on-scene time. METHODS A 1-hour interactive educational pres...

With the growth of wireless networks and mobile devices, we are moving closer towards an era of cyberphysical systems (CPSs). Such systems have the potential to benefit numerous applications in areas as diverse as military, financial, and health care. However, security issues must be addressed before CPSs can be widely deployed. The problem is serious because CPSs involve interactions between a...

Congenital portosystemic shunts (CPSS) are hepatic vascular anomalies which can affect any breed of dog or cat. Extrahepatic CPSS are most commonly observed in cats and small dogs, whereas intrahepatic CPSS are more likely to affect large breed dogs. A hereditary basis has been observed in some dog breeds. Affected animals are usually presented at young age with a variety of neurological, gastr...

The trend of digitalization provides new opportunities for industrial equipment manufactures as sensor technology and ubiquitous connectivity become part of the equipment. In particular, cyber-physical systems (CPSs) enable digital innovation for the industrial product and service business by improving operational efficiencies, facilitating innovative hybrid business models, and fuelling servit...

Capsular components of Cryptococcus neoformans induce several deleterious effects on T cells. However, it is unknown how the capsular components act on these lymphocytes. The present study characterized cellular and molecular events involved in immunoregulation of splenic CD4(+) T cells by C. neoformans capsular polysaccharides (CPSs). The results showed that CPSs induce proliferation of normal...

Hepatic encephalopathy (HE) is an important cause of morbidity and mortality in patients with liver disease. The pathogenesis of he is incompletely understood although ammonia and inflammatory cytokines have been implicated as key mediators. To facilitate further mechanistic understanding of the pathogenesis of HE, a large number of animal models have been developed which often involve the surg...

Summary Next-generation sequencing has been widely applied to understand the complexity of non-coding RNAs (ncRNAs) in the last decades. Here, we present CPSS 2.0, an updated version of CPSS 1.0 for small RNA sequencing data analysis, with the following improvements: (i) a substantial increase of supported species from 10 to 48; (ii) improved strategies applied to detect ncRNAs; (iii) more ncRN...

Cyber-Physical Systems (CPSs) are integrations of networking and distributed computing systems with physical processes, where feedback loops allow physical processes to affect computations and vice versa. Although CPSs can be found in several real-world domains (automotive, avionics, energy supply, etc), their verification often relies on simulation test systems rather then formal methodologies...

A focused theme in systems biology is to uncover design principles of biological networks, that is, how specific network structures yield specific systems properties. For this purpose, we have previously developed a reverse engineering procedure to identify network topologies with high likelihood in generating desired systems properties. Our method searches the continuous parameter space of an ...

Although capsular polysaccharide (CPS) is critical for meningococcal virulence, the molecular basis of alternative complement pathway (AP) regulation by meningococcal CPSs remains unclear. Using serum with only the AP active, the ability of strains to generate C3a (a measure of C3 activation) and subsequently deposit C3 fragments on bacteria was studied in encapsulated groups A, B, C, W135 and ...