نتایج جستجو برای: cox 1
تعداد نتایج: 2783617 فیلتر نتایج به سال:
Despite the important role of both cyclooxygenase (COX) isoforms (i.e. COX-1 and COX-2) in maintenance of hypersensitivity following peripheral nerve injury, their role in the development of neuropathic pain is not clear. The present study was undertaken to determine the effect of COX inhibitors to address the potential role of COX isozymes in the development of neuropathic pain in rats after c...
A group of regioisomeric 5-oxo-1,4,5,6,7,8 hexahydroquinoline derivatives possessing a COX-2 SO2Me pharmacophore at the para position of the C-2 or C-4 phenyl ring, in conjunction with a C-4 or C-2 phenyl (4-H) or substituted-phenyl ring (4-F,4-Cl,4-Br,4-OMe,4-Me, 4-NO2), were designed for evaluation as selective cyclooxygenase-2 (COX-2) inhibitors. These target 5-oxo-1,4,5,6,7,8 hexahydroquino...
Cyclooxygenase (COX) is the key enzyme required for the conversion of arachidonic acid to prostaglandins. Two cycloxygenase isoforms have been identified and are referred to as COX-1 and COX-2. Both enzymes are blocked by nonselective anti-inflammatory drugs (NSAID), such as indomethacin and ibuprofen. COX-1 is an enzyme normally found in tissues and is involved in physiological functions, whil...
Despite the important role of both cyclooxygenase (COX) isoforms (i.e. COX-1 and COX-2) in maintenance of hypersensitivity following peripheral nerve injury, their role in the development of neuropathic pain is not clear. The present study was undertaken to determine the effect of COX inhibitors to address the potential role of COX isozymes in the development of neuropathic pain in rats after c...
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