In this study, we synthesized a novel multifunctional benzoxazine monomer (Coumarin-COOH BZ), possessing both coumarin and COOH groups, through the reaction of 4-methyl-7-hydroxycoumarin, 4-aminobenzoic acid, and paraformaldehyde in 1,4-dioxane, with the structure confirmed using 1H and 13C nuclear magnetic resonance and Fourier transform infrared (FTIR) spectroscopy. Differential scanning calo...

To reduce the risk of hemorrhage, experts advocate prescribing the anticipated therapeutic dose to patients who are beginning coumarin therapy, but until now there was no accurate way to estimate that dose. Using pharmacogenetics-based coumarin therapy, clinicians can now estimate the therapeutic dose by genotyping their patients for single nucleotide polymorphisms (SNPs) that affect coumarin m...

Absorption and fluorescence spectra of bichromophoric coumarins were investigated in different solvents and in polymer matrices. These bichromophoric coumarins were composed of a coumarin dimethylamino-substituted at position 7 or unsubstituted coumarin and phthalimide or a 1,8-naphthylimide linked with an iminomethyl bridge to the position 3 or 8 of the coumarin ring. Absorption spectra of 7-d...

Coumarin possesses a number of biological activities like antimicrobial, anti-inflammatory, analgesic, antioxidant, anticancer, antimalarial etc. Coumarin belongs to a group of benzpyranes, which consist of a benzene ring joined to a pyran nucleus. In the present study amino derivatives bearing coumarin nucleus are synthesized from 7-hydroxy -4methyl coumarin by using mild catalyst, CAN which i...

Nystatin-resistant mutations exhibit extreme sensitivity to 1.3 mm coumarin. The mutations fall into three complementation groups so it is possible to select for nonallelic mutations conferring sensitivity to coumarin by selection on nystatin-containing nutrient agar plates. Complementation between such coumarin-sensitive mutations allows the selection of diploids on coumarin-containing nutrien...

Three new natural coumarin substances 1, 2 and 3 (derivatives of 2',2'-dimethyl-3',4'-dihydroxydihydropyrano-5',6':6,7-coumarin) were isolated from the roots and fruits of Peucedanum arenarium W.K. On the basis of the spectral data from UV, IR, and NMR spectra of coumarin 1, named peuarenarine, it was assumed, that, it is an ester of 2',2'-dimethyl-3',4'-dihydroxy-dihydropyrano5',6' :6,7-coumar...

Pentacoordinated iridium( i )-cyclooctadiene complexes featuring a coumarin-functionalised imidazoline– or benzimidazoline–NHC ligand exhibit fluxional behavior as consequence of the hemilability pyrone ring in coumarin wingtip.

Lead is a toxic substance and damages human metabolism. Coumarin-derived substances have many effects such as antioxidant, anticancer, antibacterial ones. In this study, the of 3-benzoyl-7-hydroxy coumarin on rat liver tissues under oxidative stress with lead acetate were investigated. rats divided into 4 groups. Control group (K), Coumarin (KUM), (P) Coumarin+Lead (KUMP) groups formed. Malondi...

Here we describe a coumarin-phosphine dye that undergoes activation of coumarin fluorescence upon reaction with S-nitrosothiols.