To study the response of large coronary arteries to short periods of myocardial ischemia a pair of ultrasonic dimension transducers, a flow probe and a hydraulic occluder were implanted around the left circumflex coronary artery for the instantaneous and continuous measurement of external coronary artery dimensions and coronary blood flow, respectively. At 6.1 +/- 0.4 seconds after release of a...

Background and objectives: Sedentary life style and high-fat diet are one of the key causes of coronary artery disease. The aim of this study was to evaluate effects of periodic exercise and consumption of fenugreek seed extract on the expression of oxidized low-density lipoprotein (oxLDL) and reactive oxygen species (ROS) genes in patients with coronary artery occlusion. Methods: The present ...

The present study was designed to elucidate the role of collateral development, per se, on reactive hyperemia without persistent coronary stenosis in instrumented conscious dogs. Functional states of coronary collaterals were augmented by repetitive 2 minutes of coronary occlusion every 30 minutes for 2-9 days. Regional shortening measured sonomicrometrically recovered from -1.2 +/- 6.5% of the...

OBJECTIVE To determine whether isometric exercise increases collateral flow in remote ischaemic myocardium in acute coronary occlusion models of patients with coronary artery disease. DESIGN A randomized controlled study. SUBJECTS Sixty-five patients with 1-vessel coronary artery disease. METHODS Subjects were randomly assigned to either the isometric exercise group or non-exercise group....

OBJECTIVES This study sought to assess the effects of sequential coronary artery occlusion during minimally invasive coronary artery bypass graft surgery (CABG) on hemodynamic variables and left ventricular systolic function by means of transesophageal echocardiography (TEE). BACKGROUND Clinical and experimental studies suggest a protective effect of ischemic preconditioning in patients with ...

Background: Slow coronary flow (SCF) is defined as a condition in which in spite of no evidence of coronary occlusion or stenosis in angiography, there is delayed pacification of the vessels after the injection of a contrast agent. There are several studies about electrocardiogram (ECG) changes in these patients, but changes like OLD MI, RBBB, LBBB, LVH and ST-T wave have not b...

During reactive hyperemia following a brief coronary artery occlusion, excess arterial inflow exceeds the blood flow debt incurred during occlusion by 300-600T. The present study was performed to determine whether this marked reactive hyperemia is essential for restoration of coronary vascular tone. Coronary blood flow was measured in unanesthetized dogs with electromagnetic flowmeters and hydr...

Introduction: ischemic left bundle branch block (LBBB) is coronary occlusion. We report an atypical case of de novo LBBB in relation to a tight right lesion. Material and methods: Mr H, 53 years old with no modifiable risk factors, consulted for typical angina pain evolving since 4 hours. The per-critical ECG showed complete criteria acute ischemia. Coronary angiography lesion the artery that w...

OBJECTIVES We tested whether acute coronary occlusion interferes with arterial baroreceptor control of heart rate in humans. BACKGROUND Subnormal baroreflex sensitivity (BRS) is an important risk indicator for sudden death. Animal research indicates that both chronic myocardial infarction and acute coronary occlusion impair baroreflex modulation of heart rate. METHODS We measured RR interva...

The relation of angiographically recognized coronary occlusion to regional myocardial blood flow has not been studied adequately in spite of its clinical significance. This is particularly important, as revascularization procedures, based on angiographic studies, are being performed with increasing frequency. To compare the severity of reduction in flow to the severity of coronary occlusion, re...