Serotonin is released by activated platelets and may act as a mediator to initiate or sustain certain unstable syndromes of ischemic heart disease in humans. To determine whether or not serotonin concentration increases across the coronary bed in patients with severe, limiting angina, we measured central aortic and coronary sinus serotonin concentrations by a sensitive radioenzymatic assay in 3...

Coronary computed tomography (CT) enables noninvasive, highly diagnostic visualization of coronary artery stenosis. However, identifying culprit lesions in patients with multivessel coronary artery stenoses is difficult. Cardiac single photon emission computed tomography (SPECT) shows ischemic regions with high diagnostic accuracy, although evaluating the vascular territory supplied by each cor...

Objectives. We hypothesized that atherectomy would be superior to balloon angioplasty for ostial and nonostial left anterior descending coronary artery lesions. Background. Balloon angioplasty of ostial coronary artery lesions has been associated with a lower procedural success rate and a higher rate of complications and of restenosis than angioplasty of nonostial stenoses. Directional coronary...

percutaneous coronary angioplasty (ptca) of a coronary stenosis without documented ischemia at noninvasive stress testing is often performed, but its benefit is unproven. coronary pressure– derived fractional flow reserve (ffr) is an invasive index of stenosis severity defined as the ratio of maximal blood pressure in a stenotic vessel to the normal maximal pressure in the same vessel. ffr is a...

Atherothrombotic is a systemic disease of the coronary vessel wall that causes coronary artery lesions appearing heterogeneous in morphology and chemical constitution. Disrupting or vulnerable plaques in the coronary arteries exhibit a thin fibrous cap (fibrous cap thickness 65 to 150 μm) with a large lipid core, as defined by American Heart Association AHA plaque type V-Va [1]. Acute coronary ...

BACKGROUND The coronary arterial lesions of Kawasaki disease are mainly dilative lesions, aneurysms, and stenotic lesions formed before, after, and between aneurysms; these lesions develop in multiple branches resulting in complex coronary hemodynamics. Diagnosis of myocardial ischemia and infarction and evaluation of the culprit coronary arteries and regions is critical to evaluating the treat...

AIMS The management of ostial lesions is one of the challenges of percutaneous coronary intervention (PCI) in recent medicine. Although stent implantation has increased the accuracy of the results and improved long-term outcomes, in-stent restenosis (ISR) occurs more frequency following the treatment of ostial lesions than the treatment of non-ostial lesions. When additional stenting is not des...

OBJECTIVE To compare the coronary anatomy and the location of coronary lesions in monozygotic and dizygotic twin pairs affected with coronary artery disease. DESIGN Coronary angiographic findings were compared with respect to the distribution of coronary blood supply and the location of coronary lesions. MAIN OUTCOME MEASURES Distribution of coronary blood supply, diameters and length of pr...