PURPOSE To evaluate the clinical efficacy of morselized amniotic membrane and umbilical cord tissue (MAU) in treating refractory corneal epithelial defect in ocular cicatricial diseases. METHODS Retrospective review of four patients with ocular cicatricial diseases treated with topical MAU for corneal epithelial defects refractory to conventional treatments including topical lubricants, autol...

In pharmaceutical companies and research institutes, many toxicity tests are performed with laboratory animals. This study was performed to produce reference data for eye toxicity tests and to investigate the ophthalmic diseases of 408 ICR mice and 119 BALB/c mice, which are commonly used as subjects in toxicity tests. The experimental animals without clinical disorders were selected regardless...

Corneal diseases are the third leading cause of blindness globally. Topical nonsteroidal anti-inflammatory drugs (NSAIDs), steroids, antibiotics and tissue transplantation are currently used to treat corneal pathological conditions. However, barrier properties of the ocular surface necessitate high concentration of the drugs applied in the eye repeatedly. This often results in poor efficacy and...

Corneal Pathologic Responses The normal cornea is clear, and any alteration in clarity signifies pathology. Pathologic changes include corneal vessels, edema, pigment, crystalline deposits, inflammatory cell infiltrates, destruction from degradative enzymes, and scarring. Such changes are usually non-specific and incited by numerous causes. Pathologic responses can occur singularly, but more of...

Method Secretion of both proinflammatory cytokine interleukin (IL)-1α and tumor necrosis factor (TNF)-α was measured after cultivation of 47 corneas collected from corneal graft recipients suffering from different corneal diseases. Non-inflammatory corneal diseases were keratoconus (n = 8), keratoglobus (n = 2), bullous keratopathy (n = 11), and Groenouw stromal dystrophy type II (n = 2), where...

Cornea is a major structure of eyes affected in rheumatologic patients. It is important to know corneal findings in rheumatic diseases because it can provide early diagnosis and treatment for systemic disease and reduce the risk of complications as irreversible visual loss. In this article, we will summarize and discuss the corneal findings and the formation mechanisms in the diseases of Sjogre...

purpose: to investigate the association between acute corneal hydrops in patients with keratoconus (kcn) and mitral valve prolapse (mvp). methods: this case-control study included kcn patients with corneal hydrops who were referred to labbafinejad medical center or a collaborating private clinic from march 2006 to march 2008 as the case group. the control group included age- and sex-matched ind...

One among the corneal diseases causing significant visual impairment and blindness is corneal dystrophies, which is a heterogeneous subset of hereditary corneal disorders that are generally bilateral, non-inflammatory and often result in corneal opacities, requiring corneal transplantation [1]. To add to this group and also which is closely related to dystrophy are the degenerative conditions o...

In this review, we analyzed the domestic and foreign literature on use of corneal lenticula obtained by keratorefractive surgery using SMILE technology (SMall Incision Lenticula Extraction). Research is being actively carried out a lenticular tissue for refractive purposes: correction hyperopia (LIKE – Lenticular Intrastromal Keratoplasty), presbyopia (PEARL PrEsbyopic Allogenic Refractive Lent...