The activity cliff concept has experienced increasing interest in medicinal chemistry and chemoinformatics. Activity cliffs have originally been defined as pairs of structurally similar compounds that are active against the same target but have a large difference in potency. Activity cliffs are relevant for structure-activity relationship (SAR) analysis and compound optimization because small c...

the δ18o, δ13c, and strontium/calcium (sr/ca)-record was measured from a 7-year old platygyrasinensis coral located offshore larak island in the persian gulf at a resolution of 22 samples/year. an increasedsampling resolution of 55 samples/year over two annual cycles was also compared with the 22 sampleresolution to evaluate the effectiveness of the sampling procedure. the resulting data exhibi...

The analysis of structure-activity relationships (SARs) of small bioactive compounds is a central task in medicinal chemistry and pharmaceutical research. The study of SARs is in principle not limited to computational methods, however, as data sets rapidly grow in size, advanced computational approaches become indispensable for SAR analysis. Activity landscapes are one of the preferred and wide...

Cory White and Daniel Hiranandani Computer Science Department, California Polytechnic State University, San Luis Obispo, California 93407 e-mail: [email protected], [email protected] Christopher S. Olstad Marine Resources Development Foundation, 51 Shoreland Drive, Key Largo, Florida 33037 e-mail: [email protected] Keith Buhagiar Department of Classics and Archaeology, University of Malta, M...

REFERENCES [1] S. Kay, Fundamentals of Statistical Signal Processing, Volume 1, Estimation Theory. Englewood Cliffs, NJ: Prentice Hall, 1993. [2] S. Kay, Fundamentals of Statistical Signal Processing, Volume 2, Detection Theory. Englewood Cliffs, NJ: Prentice Hall, 1998. [3] A. Leon-Garcia, Probability and Random Processes for Electrical Engineering, 2nd ed. Reading, MA: Addison-Wesley, 1994. [...

Despite a growing body of descriptive, theoretical and practical knowledge about Information Systems Development (ISD), large-scale information system development and implementation projects still fail in high numbers. The deeper causes of such failures are only partially understood. This study uses an action research approach in which prescriptions and recommendations drawn from research on an...